Results 131 to 140 of about 55,224 (387)
Journal of Biophotonics, Volume 15, Issue 12, December 2022., 2022 In ophthalmic surgery, intraoperative retinal perfusion assessment/monitoring has been suggested for numerous indications, typically using fluorescence angiography. However, applicability is limited given the difficult arrangement, associated risks and the lack of automated/objective perfusion quantification.
Tim J. Enz +9 more
wiley +1 more source
Identifying specific prefrontal neurons that contribute to autism-associated abnormalities in physiology and social behavior. [PDF]
, 2017 Functional imaging and gene expression studies both implicate the medial prefrontal cortex (mPFC), particularly deep-layer projection neurons, as a potential locus for autism pathology.
Brumback, AC +9 more
core +1 more source
Electrical Microneedles for Wound Treatment
Advanced Science, EarlyView.A review on state‐of‐art research concerning electrical microneedles applied for wound treatment is presented. After a comprehensive analysis of mechanisms of electrical stimulation on wound healing, the derived three types of electrical microneedles are clarified and summarized. Further, their applications in wound healing are highlighted.
Yu Wang +6 more
wiley +1 more source
Experimentally implemented dynamic optogenetic optimization of ATPase expression using knowledge-based and Gaussian-process-supported models [PDF]
Optogenetic modulation of adenosine triphosphatase (ATPase) expression represents a novel approach to maximize bioprocess efficiency by leveraging enforced adenosine triphosphate (ATP) turnover. In this study, we experimentally implement a model-based open-loop optimization scheme for optogenetic modulation of the expression of ATPase.
arxiv +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Since the invention of optogenetics, using light to control the activity of individual neurons and dissect the complex neural circuits has been a powerful tool for neuroscience owing to the high temporal precision and neuron-type specificity.
Xiang Wu +11 more
semanticscholar +1 more source
CAV-2 Vector Development and Gene Transfer in the Central and Peripheral Nervous Systems [PDF]
, 2019 The options available for genetic modification of cells of the central nervous system (CNS) have greatly increased in the last decade. The current panoply of viral and nonviral vectors provides multifunctional platforms to deliver expression cassettes to
Amani Wehbi +7 more
core +2 more sources
Advanced Science, EarlyView.Mitochondria across the entire neuromuscular system have been comprehensively reconstructed at different developmental stages using 3D electron microscopy. Fundamental structural principles related to synaptic function are preserved across development, and these morphologies are adapted to ensure effective neural circuit function.
J. Alexander Bae +9 more
wiley +1 more source
Optogenetics: Novel Tools for Controlling Mammalian Cell Functions with Light
International Journal of Photoenergy, 2014 In optogenetics, targeted illumination is used to control the functions of cells expressing exogenous light-activated proteins. Adoption of the optogenetic methods has expanded rapidly in recent years.
Toshihiro Kushibiki +3 more
doaj +1 more source
BioTechniques, 2014 It has been a decade since researchers first showed they could control neurons with light. Jeffrey Perkel takes a look at the technique that changed how we study the brain.
Jeffrey M. Perkel
doaj +1 more source
BMC Biology, 2021 Background Optogenetics allows the experimental manipulation of excitable cells by a light stimulus without the need for technically challenging and invasive procedures.
M. Koopman, L. Janssen, E. A. A. Nollen
doaj +1 more source