Results 131 to 140 of about 20,290 (227)

Neuropsychopharmacology of hallucinogenic and non‐hallucinogenic 5‐HT2A receptor agonists

British Journal of Pharmacology, EarlyView.
Psychedelic drugs such as LSD and psilocin were once relegated to the fringes of medical research because of their association with counterculture movements and a perceived concern about harm through recreational use, and their consequent legal prohibition in the early 1970s.
Trevor Sharp, Aurelija Ippolito
wiley   +1 more source

Transforming Epilepsy Care: A Comprehensive Review of Technological Innovations, Artificial Intelligence Advancements, and Precision Tools for Enhanced Seizure Management and Patient Outcomes. [PDF]

Scientifica (Cairo)
Shyam M, Kaushal N, Yadav M, Srirangan P, Prince SE.   +4 more
europepmc   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing. [PDF]

Neuron
Hendricks WD, Sadahiro M, Mossing D, Veit J, Adesnik H.   +4 more
europepmc   +1 more source

Feedback control of excitability and high K+ induced epileptiform bursts in male rat hippocampal slices with a photocaged adenosine A1 receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Adenosine is a potent regulator of neurotransmission and neuronal excitability, through activation of Gi coupled adenosine A1 receptors (A1Rs). Adenosine has gained interest as an anticonvulsant because of its endogenous involvement in ending seizure activity, but peripheral side effects require local application.
Erine Craey, Marijke Vergaelen, Serge Van Calenbergh, Jeroen Spanoghe, Evelien Carrette, Kristl Vonck, Paul Boon, Wytse J. Wadman, Robrecht Raedt   +8 more
wiley   +1 more source

Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead (Advanced Genetics 3/06). [PDF]

Adv Genet (Hoboken)
Duan X, Zhu M, Gao S.
europepmc   +1 more source

Spreading depolarization and its influence on epileptiform activity

Epilepsia, EarlyView.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

Retrograde optogenetics reveals sensorimotor convergence within a corticotectal pathway of non-human primates. [PDF]

Curr Biol
Yu X, Gopal A, Inoue KI, Bohlen MO, Kuczewski GM, Sommer MA, Nienborg H, Takada M, Hikosaka O.   +8 more
europepmc   +1 more source

Comparative analysis of canonical and noncanonical rhodopsins in Amphidinium carterae and Karlodinium veneficum

Journal of Phycology, EarlyView.
Abstract Rhodopsins are ancient and versatile light‐sensitive proteins, widely distributed across microbial life. In dinoflagellates, however, their diversity and function remain poorly understood, owing to the lineage's extreme genomic divergence. Here, we surveyed the rhodopsin complements of two dinoflagellates, Amphidinium carterae and Karlodinium ...
Jens Wira, Miranda Judd, Anne Baldino, Tsvetan Bachvaroff, Allen R. Place   +4 more
wiley   +1 more source

Technical development of two-photon optogenetic stimulation and its potential application to brain-machine interfaces. [PDF]

Neurophotonics
Hira R, Isomura Y.
europepmc   +1 more source