Results 241 to 250 of about 43,018 (315)

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, EarlyView.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Sensing a rainbow of colors: algal photoreceptors. [PDF]

Front Plant Sci
Hallmann A.
europepmc   +1 more source

Vascularised Brain Organoids: Engineering Strategies and Neurobiological Applications

Cell Proliferation, EarlyView.
This review highlights emerging strategies to engineer vascularized brain organoids—including endothelial co‐culture, genetic induction, perfusion systems, and in vivo transplantation—and their applications in modelling neurovascular diseases, evaluating BBB drug delivery, and advancing regenerative medicine.
Yeajin Song, Hyejin Jo, Seokchan Jeong, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Lateral hypothalamus and eating: cell types, molecular identity, anatomy, temporal dynamics and functional roles. [PDF]

Exp Mol Med
Cheon DH, Park S, Park J, Koo M, Kim HH, Han S, Choi HJ.   +6 more
europepmc   +1 more source

Optogenetic Control of Bacterial Cell‐Cell Adhesion Dynamics: Unraveling the Influence on Biofilm Architecture and Functionality [PDF]

Juan José Quispe Haro, Fei Chen, Rachel Los, Shuqi Shi, Wenjun Sun, Yong Chen, Timon Idema, Seraphine V. Wegner   +7 more
openalex   +1 more source

Restoring failed inhibition in the substantia nigra pars reticulata suppresses absence seizures in rats

Epilepsia, EarlyView.
Abstract Objective For over four decades, the substantia nigra pars reticulata (SNr) has been recognized as a critical structure in the modulation of seizure activity. Pharmacological and optogenetic inhibition of the SNr produces robust seizure suppression in a range of seizure models.
Devin Palmer, Patrick A. Forcelli
wiley   +1 more source

Spreading depolarization and its influence on epileptiform activity

Epilepsia, EarlyView.
Abstract Spreading depolarization (SD) is a transient disruption of electrographic activity that slowly propagates through the gray matter by chemical contiguity, and it is characterized by a large depolarization of neurons and glial cells. SD, which is associated with massive changes in ion homeostasis, including extreme increases in [K+]o, was shown ...
Maxime Lévesque, Rüdiger Köhling, Massimo Avoli   +2 more
wiley   +1 more source

Altered Dopamine Signaling in Extinction-Deficient Mice. [PDF]

eNeuro
Gunduz-Cinar O, Fritz EM, Xia M, Van Leer E, Crow N, Holmes A, Singewald N.   +6 more
europepmc   +1 more source

Optogenetic Approaches for Controlling Seizure Activity

, 2016
Jack K. Tung, Ken Berglund, Robert E. Gross   +2 more
openalex   +2 more sources

D1/D5 receptor activation promotes long‐term potentiation and synaptic tagging/capture in hippocampal area CA2

The FEBS Journal, EarlyView.
Activation of dopamine receptor D1 (D1R) stimulates PKA and ERK pathways via dissociation of stimulatory and olfactory G protein alpha subunits (Gαs/olf). PKA relieves striatal‐enriched protein tyrosine phosphatase (STEP) inhibition of ERK, promoting cyclic adenosine monophosphate response element‐binding protein (CREB)‐driven transcription of ...
Kevin Chua, Yee Song Chong, Sreedharan Sajikumar   +2 more
wiley   +1 more source