Results 261 to 270 of about 58,764 (371)

Levodopa Disrupts Activity Patterns and Encoding of Movement in Striatal Cholinergic Interneurons of Behaving Mice

open access: yesMovement Disorders, EarlyView.
Abstract Objectives Levodopa treatment, the gold standard therapy for Parkinson's disease, can lead to levodopa‐induced dyskinesias (LIDs). Recent studies in acute brain slices have implicated the neural dynamics of striatal cholinergic interneurons (CINs) in the pathophysiology of LID, reporting that their discharge becomes more bursty in dyskinetic ...
Yara Atamna   +6 more
wiley   +1 more source

Functional Magnetic Resonance Imaging (fMRI) Signatures of Progression and Phenoconversion in Prodromal Synucleinopathies

open access: yesMovement Disorders, EarlyView.
Abstract Background Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal manifestation of synucleinopathies and provides a critical window to identify early markers of progression to Parkinson's disease (PD) and dementia with Lewy bodies (DLB).
Lachlan Churchill   +6 more
wiley   +1 more source

Light‐Based Molecular Tools to Precisely Monitor and Operate β‐Adrenoceptors

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT β‐Adrenoceptors are important G protein–coupled receptors involved in cardiovascular, metabolic, and neurological regulation. To study their function with high precision, light‐based molecular tools have been developed offering precise spatiotemporal control.
Ignazzitto Maria Tindara   +3 more
wiley   +1 more source

MR‐ARFI to evaluate intensity variability and enhance targeting of FUS: A brain study in rats

open access: yesMagnetic Resonance in Medicine, EarlyView.
Abstract Purpose Inconsistencies in focused ultrasound (FUS) transducer positioning and skull‐induced aberrations can reduce the targeting accuracy and cause inconsistencies in the intensity delivered during FUS neuromodulation procedures. This study aimed to evaluate the use of MR‐acoustic radiation force imaging (MR‐ARFI) in improving the targeting ...
Abubakr Eldirdiri   +7 more
wiley   +1 more source

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