Results 301 to 310 of about 58,764 (371)

The Next Frontier in Parkinson's Disease Treatment: A Narrative Review of Innovative Neurosurgical and Gene Therapy Approaches. [PDF]

Health Sci Rep
Faheem MSB, Haroon-Ul-Rasheed M, Aftab R, Faheem Q, Feroze F, Ain HQU, Samadi S.   +6 more
europepmc   +1 more source

Comorbidities in the mouse model of temporal lobe epilepsy induced by intrahippocampal kainate

Epilepsia, EarlyView.
Abstract Objective Mesial temporal lobe epilepsy (MTLE) is generally associated with cognitive and psychiatric comorbidities. Here we examined whether similar comorbidities are observed in mice injected with kainate in the dorsal hippocampus, a model known to recapitulate many features of human MTLE, and if these comorbidities are sex dependent ...
Loan Samalens, Camille Beets, Clothilde Courivaud, Philippe Kahane, Antoine Depaulis   +4 more
wiley   +1 more source

Emergent biotechnology applications in urology: a mini review. [PDF]

Front Bioeng Biotechnol
Liu C, Rivera Ruiz A, Zhang Y, Zimmern P, Li Z.   +4 more
europepmc   +1 more source

Evaluating the outcomes of pluripotent stem‐cell‐derived photoreceptor transplantation in retinal repair

The FEBS Journal, EarlyView.
Transplantation of stem cell‐derived photoreceptors in retinal repair. We summarize methods for differentiating stem cells and describe surgical techniques for transplanting photoreceptor precursors to restore visual function (A). The effectiveness of these techniques is assessed with behavioral (B) and in vitro assays (C) using mouse models that mimic
Darin Zerti, Birthe Dorgau, Evelyne Sernagor, Lyle Armstrong, Majlinda Lako, Gerrit Hilgen   +5 more
wiley   +1 more source

Publisher Correction: Scattering of Sculpted Light in Intact Brain Tissue, with implications for Optogenetics. [PDF]

Sci Rep
Favre-Bulle IA, Preece D, Nieminen TA, Heap LA, Scott EK, Rubinsztein-Dunlop H.   +5 more
europepmc   +1 more source

Cell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits

, 2013
Keigo Kohara, Michele Pignatelli, Alexander J. Rivest, Hae-Yoon Jung, Takashi Kitamura, Junghyup Suh, Dominic D. Frank, Koichiro Kajikawa, Nathan Mise, Yuichi Obata, Ian R. Wickersham, Susumu Tonegawa   +11 more
openalex   +2 more sources

A guide to characterizing the dynamic mitochondria–endoplasmic reticulum contact sites

The FEBS Journal, EarlyView.
The dynamism, heterogeneity, and functional complexity of mitochondria–endoplasmic reticulum contacts (MERCs) require combined methodological approaches to offset limitations of individual techniques. Here, we review available tools and methodologies for MERC research, outline key technical challenges, and discuss how recent advances deliver ...
Antigoni Diokmetzidou, Luca Scorrano
wiley   +1 more source

Lighting the Way to Seizure Cessation: Transcranial Optogenetic Therapies to Stop Seizures in Mouse Models. [PDF]

Epilepsy Curr
Buchanan GF.
europepmc   +1 more source

rAAV-Mediated Subcellular Targeting of Optogenetic Tools in Retinal Ganglion Cells In Vivo

, 2013
Chaowen Wu, Ivanova Ea, Yi Zhang, Zhuo-Hua Pan   +3 more
openalex   +2 more sources

TDP‐43 proteinopathies and neurodegeneration: insights from Caenorhabditis elegans models

The FEBS Journal, EarlyView.
The manuscript explores structural and functional features of TDP‐43 and its worm homologue, TDP‐1, highlighting conserved and divergent structural and functional features. Using genetically engineered C. elegans models, key pathological features of TDP‐43 proteinopathies—including aggregation, neurodegeneration, and motor deficits—are recapitulated ...
Ghulam Jeelani Pir, Joerg Buddenkotte, Majid Ali Alam, Ahmed Own, Randall J. Eck, Brian C. Kraemer, Eckhard Mandelkow, Martin Steinhoff   +7 more
wiley   +1 more source