Results 331 to 340 of about 55,224 (387)

Neural Excitatory/Inhibitory Imbalance in Motor Aging: From Genetic Mechanisms to Therapeutic Challenges. [PDF]

Biology (Basel)
Chen X, Wang Y, Zhang Y, Li X, Zhang L, Gao S, Zhang C.   +6 more
europepmc   +1 more source

Use of Human In Vitro Gut Specimens for Translational Neurogastroenterology and Motility in the 21st Century

Neurogastroenterology &Motility, EarlyView.
In vitro studies with GI surgical specimens or biopsy are a critical step in translating preclinical studies in animals to humans before testing potential therapeutic interventions in expensive clinical trials. Routine availability of human gut specimens, in combination with technological advances and powerful new in vitro models of the human ENS from ...
Dmitrii Pavlov, Fievos L. Christofi
wiley   +1 more source

Optogenetics in Pancreatic Islets: Actuators and Effects. [PDF]

Diabetes
Gangemi CG, Janovjak H.
europepmc   +1 more source

Direct Stimulation of Gastric Smooth Muscle Cells via Gq Proteins With Light

Neurogastroenterology &Motility, EarlyView.
Optogenetic stimulation enables direct and selective stimulation of smooth muscle cells and thus provides a new opportunity to restore gastric contractility in cases of gastroparesis. Herein, we demonstrate that hOPN5 is a new and effective tool acting via Gq signaling and is thus complementary to light‐induced membrane depolarization with ...
David Zipf, Markus Vogt, Udhayabhaskar Sathyanarayanan, Ahmed Wagdi, Johannes Riebeling, Robert Patejdl, Tobias Bruegmann   +6 more
wiley   +1 more source

Wireless Devices for Optical Brain Stimulation: A Review of Current Developments for Optogenetic Applications in Freely Moving Mice. [PDF]

Cell Mol Bioeng
Silva P, Jacinto L.
europepmc   +1 more source

Multi‐Omics Analyses Reveal the Red and Far‐Red Light Combination Enhancing Heterologous Protein and Metabolite Production in Nicotiana benthamiana

Plant, Cell &Environment, EarlyView.
ABSTRACT Transient expression of exogenous protein in Nicotiana benthamiana leaves via agroinfiltration offers a rapid and efficient platform for functional gene discovery and heterologous production of valuable eukaryotic proteins and metabolites. Though light quality is an important factor for plant photomorphogenesis, its impact on the efficiency of
Yating Zhang, Fengjiao Wang, Ran Du, Tao Li, Shaoqun Zhou, Jianbin Yan, Wei Li   +6 more
wiley   +1 more source

Two-photon optogenetics-based assessment of neuronal connectivity in healthy and chronic hypoperfusion mice. [PDF]

Neurophotonics
Yoshioka M, Takahashi M, Kershaw J, Handa M, Takada A, Takuwa H.   +5 more
europepmc   +1 more source

Optogenetic Gq Signaling in Cardiomyocytes

, 2013
Thomas Beiert, Tobias Bruegmann, Bernd K. Fleischmann, Philipp Sasse   +3 more
openalex   +1 more source

Genome‐wide DNA methylation profiles in the raphe nuclei of patients with autism spectrum disorder

Psychiatry and Clinical Neurosciences, EarlyView.
Aim Autism spectrum disorder (ASD) has a strong genetic basis, yet its genetic complexities remain elusive. Current research highlights environmental factors and epigenetic processes, such as DNA methylation, as crucial in ASD development. This exploratory study addresses a gap in understanding epigenetic regulation in the dorsal raphe (DR)—a region ...
Keiko Iwata, Kazuhiko Nakabayashi, Keisuke Ishiwata, Kazuhiko Nakamura, Yosuke Kameno, Kenichiro Hata, Hideo Matsuzaki   +6 more
wiley   +1 more source

Optogenetic methods to stimulate gamma motor neuron axons ex vivo

Experimental Physiology, EarlyView.
Abstract It is challenging to stimulate gamma motor neurons, which are important regulators of muscle spindle afferent function, without also recruiting alpha motor neurons. Here, we test the feasibility of stimulating gamma motor neuron axons using optogenetics in two transgenic mouse lines. We used an ex vivo muscle–nerve preparation in adult mice to
Apoorva Karekal, Remie Mandawe, Cameron Chun, Sai Kiran Byri, Danitza Cheline, Serena Ortiz, Shawn Hochman, Katherine A. Wilkinson   +7 more
wiley   +1 more source