Results 71 to 80 of about 30,706 (198)

Phase 2 Study of Anti-Human Cytomegalovirus Monoclonal Antibodies for Prophylaxis in Hematopoietic Cell Transplantation. [PDF]

, 2020
Human cytomegalovirus (HCMV) can cause significant disease in immunocompromised patients, and treatment options are limited by toxicities. CSJ148 is a combination of two anti-HCMV human monoclonal antibodies (LJP538 and LJP539) that bind to and inhibit ...
Akard, Luke, Chemaly, Roy, Christoph, Sandra, Gerbitz, Armin, Hiemenz, John, Holler, Ernst, Hwang, William YK, Jang, Junho, Koh, Liang Piu, Lee, Dong-Gun, Logan, Aaron C, Long, Gwynn, Maertens, Johan, Mielke, Stephan, Pertel, Peter, Ramachandra, Sangana, Segal, Florencia, Smith, Kristin, Tang, Jih-Luh, Wang, Po-Nan, Winkler, Julia, Yeh, Su-Peng, Yeo, Adeline   +22 more
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Dynamics of anticancer drug use in Russian hospitals: a five-year retrospective analysis

Фармакоэкономика
Background. Pharmaceutical provision for oncology patients involves complex and controversial issues, particularly the use of oral anticancer drugs (ACDs) in day hospitals. These facilities often distribute oral medications for outpatient use, leading to
J. A. Agafonova, V. V. Omelyanovskiy
doaj   +1 more source

Phase I dose-escalation trial of the oral AKT inhibitor uprosertib in combination with the oral MEK1/MEK2 inhibitor trametinib in patients with solid tumors. [PDF]

, 2020
PurposeThis study aimed to determine the safety, tolerability, and recommended phase II doses of trametinib plus uprosertib (GSK2141795) in patients with solid tumors likely to be sensitive to MEK and/or AKT inhibition.MethodsThis was a phase I, open ...
Becerra, Carlos, D'Amelio, Anthony M, Ellis, Catherine, Gauvin, Jennifer, Gonzalez, Rene, Heist, Rebecca S, Ibrahim, Nageatte, Kalyana-Sundaram, Shanker, Kleha, Joseph F, Kurzrock, Razelle, Leonowens, Cathrine, Means-Powell, Julie, Tan, Antoinette R, Tolcher, Anthony W, Valero, Vincente, Wang, Chenxi, Werner, Theresa L, Yan, Li   +17 more
core  

Safety of higher dosages of Viscum album L. in animals and humans - systematic review of immune changes and safety parameters [PDF]

, 2011
Background Viscum album L extracts (VAE, mistletoe) and isolated mistletoe lectins (ML) have immunostimulating properties and a strong dose-dependent cytotoxic activity.
Gunver S Kienle, Renate Grugel, Helmut Kiene   +2 more
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Palbociclib has no clinically relevant effect on the QTc interval in patients with advanced breast cancer. [PDF]

, 2018
The aim of this study was to assess the potential effects of palbociclib in combination with letrozole on QTc. PALOMA-2, a phase 3, randomized, double-blind, placebo-controlled trial, compared palbociclib plus letrozole with placebo plus letrozole in ...
Durairaj, Chandrasekar, Ettl, Johannes, Finn, Richard S, Gauthier, Eric R, Hoffman, Justin T, Huang, Xin, Joy, Anil A, Lu, Dongrui R, Rugo, Hope S, Ruiz-Garcia, Ana, Wang, Diane D, Wilner, Keith D, Zheng, Jenny   +12 more
core   +2 more sources

Environmental Outcomes of Reducing Medication Waste by Redispensing Unused Oral Anticancer Drugs

JAMA Network Open
ImportanceMedications are associated with substantial environmental outcomes, yet frequently end up being unused by patients. Waste-minimizing interventions, such as redispensing of quality-approved oral anticancer drugs remaining unused by patients at home, could reduce the environmental footprint of cancer treatment.ObjectivesTo assess the ...
Smale, E.M., Ottenbros, A.B., Ottenbros, A.B., van den Bemt, B.J.F, Heerdink, E.R., Verploegen, Jelle, van Zelm, R., Egberts, T.C., Bekker, C.L.   +8 more
openaire   +4 more sources

A community-based advanced nurse practitioner-led integrated oncology care model for adults receiving oral anticancer medication: a pilot study

Pilot and Feasibility Studies
Oral anti-cancer medications (OAMs) are being used increasingly within cancer care. OAMs offer the potential to improve patient convenience and increase hospital capacity.
Janice P. Richmond, Mary Grace Kelly, Alison Johnston, Patrick J. Murphy, Laura O’Connor, Paddy Gillespie, Anna Hobbins, Alberto Alvarez-Iglesias, Andrew W. Murphy   +8 more
doaj   +1 more source

Exploration of novel diazinyl–thiazole based derivatives as potential antitumor agents: synthesis, in vitro screening, and computational assessment

Scientific African
Antitumour drugs and antidepressants for Alzheimer's disease (AD) share similar mechanisms of action, highlighting the potential for developing compounds that can target both conditions simultaneously.
Hend A. Almahjani, Mastoura M. Edrees, Nadia S. Al-Kaff, Musa A. Said   +3 more
doaj   +1 more source

Inhibitory effect of calotropis gigantea extract on ovalbumin-induced airway inflammation and arachidonic acid induced inflammation in a murine model of asthma [PDF]

, 2011
The root of Calotropis gigantea has been reported as a traditional folkloric medicine in treatment of asthma in the Indian literature. Root contain α-and β-amyrin are reported to possess anti-lipoxygenase activity.
Vipin Bulani, Kailash Biyani, Ravindra Kale, Unmesh Joshi, Kishor Charhate, Dinesh Kumar, Ramesh Pagore, Int J Cur Bio Med Sci.
core  

An expert consensus for the management of chronic hepatitis B in Asian Americans. [PDF]

, 2018
BACKGROUND: Hepatitis B virus (HBV) infection is common with major clinical consequences. In Asian Americans, the HBsAg carrier rate ranges from 2% to 16% which approximates the rates from their countries of origin.
Abbas, Abbas, Ahn, Beasley, Beasley, Bisceglie, Bogr, Brown, Buti, Centers for Disease Control, Chae, Chan, Chang, Chang, Chang, Chang, Chang, Chao, Chaung, Chen, Chen, Chen, Chen, Chi, Chien, Choe, Chu, Clemente, Della Corte, European Association for the Study of the Liver, Evans, Fang, Fattovich, Fontana, Fung, Gish, Hadziyannis, Halperin, Hann, Heathcote, Hongthanakorn, Hoofnagle, Hu, Huang, Hung, Hyun, Iino, Iloeje, Jeng, Keeffe, Kim, Komatsu, Konstantinou, Kowdley, Kuo, Kwong, Lai, Lai, Lai, Lai, Lampertico, Lau, Lau, Lee, Lee, Liang, Liaw, Liaw, Liaw, Liew, Lin, Lin, Lin, Liu, Liu, Liu, Lok, Lok, Lok, Loomba, MacLachlan, Manegold, Marcellin, Marcellin, Marcellin, Marcellin, Marcellin, Marcellin, Martin, Martin-Carbonero, Mast, McClune, McMahon, Mitchell, Monte, Murata, Mutimer, Nafa, Nguyen, Nguyen, Nikolopoulos, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Pan, Papatheodoridis, Park, Park, Park, Patterson, Perrillo, Perrillo, Pollack, Prati, Qiu, Reijnders, Sarin, Seto, Seto, Sherman, Shim, Shiraki, Sinatra, Sinn, Soriano, Stevens, Takano, Takayama, Takkenberg, Terrault, Thibault, Thio, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tong, Tse, Wang, Wedemeyer, Wei, Wen, Wiseman, Wursthorn, Xie, Xu, Yi, Yi, Yu, Yu, Yuen, Yuen, Yuen, Yuen, Yuen, Zhang, Zhang, Zhang, Zou   +173 more
core   +2 more sources