Results 241 to 250 of about 4,901,377 (308)

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Downregulation of KRTAP2-3 Suppresses Proliferation and Tumor Formation of Oral Cancer Cells via Inactivation of KRAS Signals. [PDF]

Cancer Sci
Miao Q, Huang Z, Takahashi K, Ibi H, Miyazono K, Podyma-Inoue KA, Watabe T.   +6 more
europepmc   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

A model-based selection of oral cancer patient for passive scattering proton beam therapy. [PDF]

J Radiat Res
Narita Y, Takayama K, Kato T, Komori S, Seto I, Nakasato T, Murakami M.   +6 more
europepmc   +1 more source

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Cultural Competence: An Overlooked Factor in the Early Diagnosis of Oral Cancer? [PDF]

Oral Dis
da Cruz Perez DE, de Lima GG, Oliveira FGDF, Dos Anjos Pontual A, da Silva Feitosa D.   +4 more
europepmc   +1 more source

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Lai et al. find that m6A reader YTHDC1 is specifically overexpressed in triple‐negative breast cancer (TNBC) and orchestrates glucose and glutamine metabolism in an m6A‐dependent manner to confer robust adaptability to lethal metabolic stress. Leveraging YTHDC1 knockdown‐induced metabolic vulnerability, an ATF4 mRNA‐targeted nanotherapy is developed to
Zheng‐Hao Lai, Yi Wang, Na‐Na Li, Ling Zeng, Renzhong Liu, Xue Li, Cheukfai Li, Xin‐Yu Ma, Wenkui Fu, Yingsen Tang, Jinjin Chen, Ning Liao, Man‐Li Luo   +12 more
wiley   +1 more source

Bridging the Health Literacy Gap for Patients With Oral Cancer: Readability Enhancement With AI Chatbots. [PDF]

J Oral Pathol Med
Baczynska A, Rehman U, Gohari SS, Chu K, Sarwar MS, Brennan PA.   +5 more
europepmc   +1 more source

Systematic verification of saliva-based biosignatures for oral cancer via targeted metabolomics. [PDF]

J Food Drug Anal
Hsieh YJ, Chang Y, Yang C, Teng NH, Yu JS, Chang KP, Chen WC, Chu LJ, Chen YT.   +8 more
europepmc   +1 more source

Molecular effects of areca nut-derived compounds on human oral cancer cells: a systematic review of in vitro evidence. [PDF]

J Oral Biol Craniofac Res
Ayna VKP, Tampubolon IA, Widowati K, Sarasati A, Ayuningtyas NF, Surboyo MDC.   +5 more
europepmc   +1 more source