Results 91 to 100 of about 288,247 (292)

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

A SYSTEMATIC EXAMINATION OF THE MUCOUS MEMBRANE OF THE MOUTH (ORAL MUCOUS MEMBRANE) – THE WAY TO PREVENT MALIGNANCIES

Український стоматологічний альманах, 2018
The article presents information on the liability of the dentist to reduce the risk of pathological processes development, including malignant neoplasms in the oral cavity.
I. K. Lutskaya, S. V. Latysheva
doaj  

Alzheimer’s disease and oral manifestations: a bi-directional Mendelian randomization study

Frontiers in Neurology
BackgroundEpidemiological studies have provided evidence suggesting an association between Alzheimer’s disease (AD) and various oral manifestations. However, conflicting conclusions have been drawn, and whether a causal association truly exists remains ...
Jingxuan Huang, Aiping Deng, Aiping Deng, Yunshuang Bai, Yunshuang Bai, Chunyu Li, Huifang Shang   +6 more
doaj   +1 more source

Allergic manifestations in oral cavity [PDF]

Acta Stomatologica Naissi, 2018
Introduction: An allergy is the failed defensive effort of the organism against foreign antigens. Reintroduction of the same foreign substance into the organism causes a reaction that leads to the destruction of one's own tissue.
Minić Ivan, Pejčić Ana, Obradović Radmila, Mirković Dimitrije, Bradić Marija   +4 more
doaj  

Oral Lesions Associated with COVID-19 and the Participation of the Buccal Cavity as a Key Player for Establishment of Immunity against SARS-CoV-2 [PDF]

, 2022
José Roberto Gutiérrez-Camacho, Lorena Ávila-Carrasco, Maria Calixta Martínez-Vázquez, Idalia Garza‐Veloz, Sidere Monserrath Zorrilla-Alfaro, Veronica Gutierrez-Camacho, Margarita L. Martínez‐Fierro   +6 more
openalex   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

State of local immunity in patients with chronic apical periodontitis

Эндодонтия Today, 2020
The aim of this study was to determine the status of local immunity in the oral cavity of patients with chronic apical periodontitis before and after management of endodontic treatment.

doaj  

Host‐Directed Antiviral Activity of SB2960 Through Selective Induction and Remodeling of Stress Granules

Advanced Science, EarlyView.
Amid the ongoing threat of emerging viral pathogens, host‐directed antivirals offer a strategy to overcome viral mutation and drug resistance. SB2960, a small‐molecule inducer of stress granules (SGs), exhibits potent broad‐spectrum antiviral activity with minimal cytotoxicity.
Wan Gi Byun, Sumin Son, JinAh Lee, Minha Lee, Meehyun Ko, Songrui Zhao, Ju Hee Kim, Kannan Vaithegi, Ji Hoon Kwon, Jung Ho Lee, Sangeun Jeon, Dawon Yi, Peng Zou, Seungtaek Kim, Seung Bum Park   +14 more
wiley   +1 more source

Diagnostic Challenges of Traumatic Ulcerative Granuloma with Stromal Eosinophilia in the Hard Palate

Diagnostics
Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign lesion that may arise from the oral mucosa consisting in an ulcerative lesion usually localized in the tongue or cheek. Palate localization is very rare.
Giacomo Setti, Stefania Caramaschi, Giuseppe Barile, Antonio d’Amati, Marta Forte, Giuseppe D’Albis, Pierantonio Bellini, Giovanna Garuti, Luisa Limongelli, Saverio Capodiferro   +9 more
doaj   +1 more source