Results 51 to 60 of about 4,731,590 (293)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Topical Formulations for Oral Cavity Cancer
, 2021 This dissertation is on aspects of oral cancer, its diagnosis, treatment and some complications that may arise in those patients being treated for the condition.
Uwaga, Rehoboth
core
Alzheimer’s disease and oral manifestations: a bi-directional Mendelian randomization study
Frontiers in NeurologyBackgroundEpidemiological studies have provided evidence suggesting an association between Alzheimer’s disease (AD) and various oral manifestations. However, conflicting conclusions have been drawn, and whether a causal association truly exists remains ...
Jingxuan Huang +6 more
doaj +1 more source
Clinical Efficacy of Primary Tumor Volume Measurements: Comparison of Different Primary Sites [PDF]
Clinical and Experimental Otorhinolaryngology, 2009 ObjectivesThe purpose of study was to determine the clinical efficacy of primary tumor volume measurements of different primary sites in the oropharynx compared to the oral cavity.MethodsA retrospective analysis of 85 patients with oral cavity or ...
Eun-Jae Chung +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Microbiome and Cancer in the Oral Cavity: A Bioinformatics Perspective [PDF]
The relationship between microbiome and cancer in the oral cavity has been under intense scrutiny over the past decade due to the advancement in next-generation sequencing.
Ming-Lun Hsu +3 more
core +1 more source
Arthritis Care &Research, EarlyView.Objective Orofacial manifestations are significantly impactful in patients with systemic sclerosis (SSc) yet remain understudied, with no dedicated clinical guidelines to inform their management. Methods An international online survey comprised38 questions addressing orofacial manifestations of SSc, including patients’ confidence in their treating ...
Eleni Deligianni +4 more
wiley +1 more source
Bacteria in the oral cavity of individuals consuming intoxicating substances.
PLoS ONE, 2023 Food habits and oral hygiene are critical attributes for physiochemical environment of the oral cavity. Consumption of intoxicating substances such as betel nut ('Tamul'), alcohol, smoking and chewing tobacco may strongly influence the oral ecosystem ...
Reyaz Ahmad Khan +4 more
doaj +1 more source