Results 31 to 40 of about 15,285 (226)

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

The Oral Contraceptive Pill and Adolescents' Mental Health

SSRN Electronic Journal, 2023
What is the impact of the oral contraceptive pill on the mental health of adolescent girls? Using administrative data from Denmark and exploiting the variation in the timing of pill initiation in an event study design, we find that the likelihood of a depression diagnosis and antidepressant use increases shortly after pill initiation.
Costa-Ramon, Ana, Daysal, Meltem, Rodríguez-González, Ana   +2 more
openaire   +5 more sources

A White Paper on Advancing Long‐Acting Therapeutics for Maternal and Pediatric Health by Bridging Gaps in Clinical Research, Access and Regulation

Clinical Pharmacology &Therapeutics, EarlyView.
As use cases for long‐acting therapeutics expand across clinical indications, there is a critical need to ensure the inclusion of women who are pregnant or breastfeeding, infants and children—populations with a historical gap in the availability of interventions already approved for use in adults.
Moherndran Archary, Robert Bies, Osei Boateng, Rachel Daley, Pierre Gashema, Mili Karina, Emily Njuguna, Sharon Nachman, Nathaniel Nkrumah, Carolyne Odula, Andrew Owen, Ethel D. Weld, Prajith Venkatasubramanian, Adeniyi Olagunju, on behalf of the Community of Practice for Long‐acting Therapeutics for Maternal and Paediatric Health, Rana Abutaima, Dorothy Akongo, Abdulnaser Alsharaa, Moherndran Archary, Shakir Atoyebi, Benoit Bestgen, Robert Bies, Osei Boateng, Andrew Butler, Edmund Capparelli, Rachel Daley, Layla Davies, Joelle Dountio, Henry Enzama, Pierre Gashema, Katila George, Dan Hawcutt, Rene Holm, Patrick Gad Iradukunda, Elodie Jambert, Mili Karina, Linda Lewis, Grace Miheso, Sebastien Morin, Andrew Morrison, Sharon Nachman, Shadia Nakalema, Emily Njunga, Nathaniel Nkrumah, Carolyne Odula‐Obonyo, Brenda Okware, Adeniyi Olagunju, Andrew Owen, Martina Penazzato, Natella Rakhmanina, Mphako Brighton Ratlabyana, Rachel Scott, Kimberly Struble, Andre‐Marie Tchouatieu, Catherine Unsworth, Prajith Venkatasubramanian, Catriona Waitt, Ethel Weld, Janine Winterbottom, Leena Zino   +59 more
wiley   +1 more source

Painful bruising: Gynecology, hematology, or just pill bias? A case report

Case Reports in Women's Health, 2023
A 23-year-old woman, G0, presented to the emergency department with painful bruising of the legs shortly after starting an oral contraceptive pill. The presumed diagnosis was pill-induced ecchymosis, and she was instructed to discontinue the medication ...
Gabriela Villamor, Deborah Winograd, Jonathan D. Baum   +2 more
doaj   +1 more source

Comorbid Depression in Hospitalised Youth With Anorexia Nervosa: Characteristics, Correlates, and Impact on Weight Gain and Treatment Duration

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is associated with high rates of comorbidities. The impact of comorbid depression‐spectrum disorders (DSDs) in AN patients on the outcomes of inpatient treatment is insufficiently studied. Method Retrospective study of youth with AN (9–18 years), admission weight < 10th body mass index (BMI) percentile ...
Antonia Wiese, Sabine Arnold, Sarah Zaid, Antonia E. Müller, Christoph U. Correll, Charlotte Jaite   +5 more
wiley   +1 more source

MONOPHASIC AND THREEPHASIC ORAL CONTRACEPTIVE PILLS, A RANDOMIZED CLINICAL TRIAL ON THEIR SIDE EFFECTS

نشریه پرستاری ایران, 2004
Oral contraceptive pills are the most effective reversible form of available contraceptive methods. Patient's noncompliance in the use of oral contraceptives is due to untoward side effects.
O. Zare, F. Shahpoorian, M. Kashanian, F. Hosseini   +3 more
doaj  

Oral health status among women with oral contraceptives [PDF]

Al-Rafidain Dental Journal, 2004
The present study was conducted to investigate the safety and efficacy of oral contraceptive drugs on oral health and to determine the prevalence of dental caries, plaque, calculus and gingival indices.
Karama MT Al–Nuaimy
doaj   +1 more source

ORAL CONTRACEPTIVE PILLS CONSUMPTION AND CEREBRAL VENOUS THROMBOSIS

ARYA Atherosclerosis, 2010
   BACKGROUND: Causes of cerebral venous thrombosis (CVT) vary around the world. Oral contraceptive pills (OCP) are among the most frequent causes of cerebral venous thrombosis.
Kavian Ghandehari, Hadi Akhbari, Mehdi Shams, Abolfazl Atalu, Azadeh Afzalnia, Fahime Ahmadi, Mojtaba Khazaei, Mohsen Kalhor   +7 more
doaj  

Emerging Options for Emergency Contraception

Clinical Medicine Insights: Reproductive Health, 2013
Emergency post-coital contraception (EC) is an effective method of preventing pregnancy when used appropriately. EC has been available since the 1970s, and its availability and use have become widespread.
Atsuko Koyama, Laura Hagopian, Judith Linden   +2 more
doaj   +1 more source