Results 1 to 10 of about 2,984,423 (243)

Challenges and Recent Progress in Oral Drug Delivery Systems for Biopharmaceuticals

Pharmaceutics, 2019
Routes of drug administration and the corresponding physicochemical characteristics of a given route play significant roles in therapeutic efficacy and short term/long term biological effects.
Bahman Homayun, Xueting Lin, Hyo-Jick Choi   +2 more
doaj   +3 more sources

Stabilization of Self-Pressurized Gelatin Capsules for Oral Delivery of Biologics [PDF]

Pharmaceutics
Background/Objectives: Oral delivery of biologics offers advantages for patient access and adherence compared to injection, but suffers from low bioavailability due to mucosal barriers and drug degradation in the gastrointestinal tract.
Amy J. Wood-Yang, Joshua I. Palacios, Abishek Sankaranarayanan, Mark R. Prausnitz   +3 more
doaj   +2 more sources

Efficacy of Intra-Articular Injection of Botulinum Toxin Type A (IncobotulinumtoxinA) in Temporomandibular Joint Osteoarthritis: A Three-Arm Controlled Trial in Rats

Toxins, 2023
Temporomandibular disorders (TMD) are complex pathologies responsible for chronic orofacial pain. Intramuscular injection of botulinum toxin A (BoNT/A) has shown effectiveness in knee and shoulder osteoarthritis, as well as in some TMDs such as ...
Marie Béret, Florent Barry, Maria-Jose Garcia-Fernandez, Henry Chijcheapaza-Flores, Nicolas Blanchemain, Feng Chai, Romain Nicot   +6 more
doaj   +1 more source

Central giant cell granuloma of the mandibular condyle: additional case and literature review

Journal of Oral Medicine and Oral Surgery, 2022
Introduction: Central giant cell granuloma (CGCG) of the jaws is not a common lesion. Only five cases are reported in the mandibular condyle. Observation: A 25 year-old male presented with preauricular swelling and a premature occlusal contact on the ...
Marti-Flich Lucas, Schlund Matthias, Nicot Romain   +2 more
doaj   +1 more source

A PEGylated Nanostructured Lipid Carrier for Enhanced Oral Delivery of Antibiotics

Pharmaceutics, 2022
Antimicrobial resistance is a major concern for public health throughout the world that severely restricts available treatments. In this context, methicillin-resistant Staphylococcus aureus (MRSA) is responsible for a high percentage of S.
Seyed Ebrahim Alavi, Urooj Bakht, Maedeh Koohi Moftakhari Esfahani, Hossein Adelnia, Seyed Hossein Abdollahi, Hasan Ebrahimi Shahmabadi, Aun Raza   +6 more
doaj   +1 more source

Isolation and characterization of ginseng-derived exosome-like nanoparticles with sucrose cushioning followed by ultracentrifugation

SN Applied Sciences, 2022
Ginseng is a traditional medicine that has been used for millennia. Asian ginseng (Panax ginseng Meyer) has multiple pharmacological properties. To determine the efficacy of ginseng-derived exosome-like nanoparticles (GDEs), GDEs should be isolated and ...
Jisu Kim, Yeon-Hee Lee, Jianxin Wang, Youn Kyung Kim, Il Keun Kwon   +4 more
doaj   +1 more source

Oral delivery of glutathione: antioxidant function, barriers and strategies

Acta Materia Medica, 2022
Glutathione (GSH) is a tripeptide with potent antioxidant activity, which is involved in numerous basic biological processes and has been used for interventions in various degenerative diseases.
Tielan Wei, Sachin Sunil Thakur, Mengyang Liu, Jingyuan Wen   +3 more
doaj   +1 more source

Prodrug Integrated Envelope on Probiotics to Enhance Target Therapy for Ulcerative Colitis

Advanced Science, 2023
Ulcerative colitis (UC), affecting millions of patients worldwide, is associated with disorders of the gut microbiota. Probiotics‐based therapy positively regulating the community structure of gut microbiota is regarded as an efficient intervention for ...
Kun Zhang, Li Zhu, Yuan Zhong, Lixin Xu, Chunhui Lang, Jian Chen, Fei Yan, Jiawei Li, Juhui Qiu, Yidan Chen, Da Sun, Guixue Wang, Kai Qu, Xian Qin, Wei Wu   +14 more
doaj   +1 more source

Systems Biology and Peptide Engineering to Overcome Absorption Barriers for Oral Peptide Delivery: Dosage Form Optimization Case Study Preceding Clinical Translation

Pharmaceutics, 2023
Oral delivery of peptides and biological molecules promises significant benefits to patients as an alternative to daily injections, but the development of these formulations is challenging due to their low bioavailability and high pharmacokinetic ...
Puneet Tyagi, Chandresh Patel, Kimberly Gibson, Fiona MacDougall, Sergei Y. Pechenov, Sarah Will, Jefferson Revell, Yue Huang, Anton I. Rosenbaum, Kemal Balic, Umar Maharoof, Joseph Grimsby, J. Anand Subramony   +12 more
doaj   +1 more source

Acyclovir-Loaded Solid Lipid Nanoparticles: Optimization, Characterization and Evaluation of Its Pharmacokinetic Profile

Nanomaterials, 2020
Acyclovir is an antiviral drug used for the treatment of herpes simplex virus infection. Its oral bioavailability is low; therefore, frequent and high doses are prescribed for optimum therapeutic efficacy.
Haniza Hassan, Ramatu Omenesa Bello, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir   +6 more
doaj   +1 more source