Results 131 to 140 of about 4,484,225 (267)

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Estudo físico-químico dos polimorfos da progesterona e estabilização da forma metaestável sobre matrizes poliméricas [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em FarmáciaA nucleação heterogênea induzida por polímeros (PIHn) é uma técnica inovadora utilizada no "screening" de polimorfos na ...
Sibaja, Andrea Mariela Araya
core  

Biowaiver monographs for immediate-release solid oral dosage forms: Stavudine

, 2012
Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of immediate-release (IR) solid oral dosage forms containing stavudine (d4T) are reviewed.
Storpirtis, Silvia, Silva, Arthur L. L., Shah, Vinod P., Barends, Dirk M., Dressman, Jennifer B., Stavchansky, Salomon, Cristofoletti, Rodrigo, Sousa, Varley D., Junginger, Hans E.   +8 more
core   +1 more source

Sound effects : The oral/aural dimensions of literature in English Introduction [PDF]

, 2011
Sound Effects traces the history of the relationship between oral conditions and aural effect in English literature from its beginnings in the Anglo-Saxon period through to the twenty-first century. Few collections nowadays, other than textbook histories,
Rhodes, Neil, Jones, Chris
core   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

FLOATING GASTRO-RETENTIVE DOSAGE FORMS - A NOVEL APPROACH FOR TARGETED AND CONTROLLED DRUG DELIVERY

, 2012
Controlled (modified) release dosage forms are one of the key concepts in drug delivery, leading to enhanced drug bioavailability and increased patient’s compliance.
Aleksandar Aleksovski
core  

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

The potential of three-dimensional printing for pediatric oral solid dosage forms

Acta Pharmaceutica
Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compounding liquid ...
Kreft Klemen, Fanous Marina, Möckel Volker   +2 more
doaj   +1 more source

Young patients' involvement in a composite endpoint method development on acceptability for paediatric oral dosage forms. [PDF]

Res Involv Engagem, 2023
Reidemeister S, Nafria Escalera B, Marín D, Balayla J, Klingmann I, Klingmann V.   +5 more
europepmc   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source