Results 171 to 180 of about 4,484,225 (267)

Correction: Colour of medicines and children's acceptability: What children think of the colour of oral dosage forms? [PDF]

Front Drug Deliv
Frontiers Production Office.
europepmc   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Colour of medicines and children's acceptability: What children think of the colour of oral dosage forms? [PDF]

Front Drug Deliv
Alessandrini E, Gizurarson S, Walsh J, Turner R, Schaufelberger D, Iurian S, Batchelor H, Klein S, Nafria B, Dicks P, Gaillard S, Franz AR, Albano J, Wisniewski A, Vermehren C, Gade C, Andersen JT, Tuleu C.   +17 more
europepmc   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

AQbD-assisted HPLC method for simultaneous determination of methylparaben and propylparaben in liquid oral dosage forms. [PDF]

Sci Rep
Darraj R, Haroun M, Abbood A, Alghoraibi I.   +3 more
europepmc   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

Biowaiver monograph for immediate-release solid oral dosage forms: Amlodipine besylate. [PDF]

J Pharm Sci
de la Cruz-Cruz P, García MA, Pérez-Urizar JT, Abrahamsson B, Cristofoletti R, Kambayashi A, Mehta M, Parr A, Polli JE, Shah VP, Charoo N, Talath S, Dressman J, Langguth P.   +13 more
europepmc   +1 more source

A Bayesian population physiologically based pharmacokinetic absorption modeling approach to support generic drug development: application to bupropion hydrochloride oral dosage forms. [PDF]

J Pharmacokinet Pharmacodyn, 2021
Hsieh NH, Bois FY, Tsakalozou E, Ni Z, Yoon M, Sun W, Klein M, Reisfeld B, Chiu WA.   +8 more
europepmc   +1 more source

A Spatially Directed Microneedle Patch Enables Intratumoral Co‐Delivery of FOLFIRINOX, Surufatinib, and Anti‐PD‐1 for Chemo‐Immunotherapy of Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
A double‐layered shell‐core microneedle patch is developed to co‐deliver FOLFIRINOX, surufatinib, and anti‐PD‐1 for localized chemo‐immunotherapy of PDAC. This strategy achieves sustained tumor suppression, reduces metastasis, and reprograms the TME by enhancing CD8+ T‐cell infiltration and inhibiting Tregs and M2 macrophages infiltration, while ...
Tingting Kong, Ximo Xu, Xiao Zhang, Chuntao Wu, Zhengjun Qiu, Beiyuan Hu, Zihao Qi, Qiang Tian, Yuqin Yang, Hanguang Dong, Fei Wu, Tuo Jin, Yan Zheng, Jiang Long   +13 more
wiley   +1 more source

Oral dosage forms of oleanolic acid and their pharmacokinetics

, 2009
Oleanolic acid (OA), a naturally occurring pentacyclic triterpenoid, is a biologically active marker compound commonly present in Chinese herbs, such as Fructus Ligustri Lucidi, Fructus Forsythiae and Radix Ginseng etc.
Xi, Jia, Tang, Hai Yi, Zheng, Ying
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