Results 171 to 180 of about 6,104,462 (286)

6-(Methylsulfinyl) Hexyl Isothiocyanate Inhibits IL-6 and CXCL10 Production in TNF-α-Stimulated Human Oral Epithelial Cells. [PDF]

Curr Issues Mol Biol, 2022
Shimoyama M, Hosokawa Y, Hosokawa I, Ozaki K, Hosaka K.   +4 more
europepmc   +1 more source

Uhrf1‐Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease

Advanced Science, EarlyView.
Uhrf1‐mediated PKM2 ubiquitination and degradation repressed the nuclear translocation of PKM2, and EPT served as a molecular glue capable of targeting the Uhrf1–PKM2 complex to alleviate the IBD course, suggesting that the Uhrf1–PKM2 axis was a previously unrecognized strategy for treating IBD.
Juan Zhang, Xin‐Rong Xu, Hui‐Lin Zhang, Qi‐Meng Zhu, Xin‐Yuan Li, Xi‐Peng Shang, Jing‐Hui Du, Christophe Morisseau, Feng Qiu, Cheng‐Peng Sun   +9 more
wiley   +1 more source

Differential Effects of Apigenin on Normal and Squamous Oral Epithelial Cells Reveal Redox-Autophagy Signaling Vulnerabilities in OSCC. [PDF]

Int J Mol Sci
Voicu Balasea B, Stan MS, Dinescu M, Imre M, Radulescu R, Cernega A, Musteanu M, Ripszky A, Pituru SM.   +8 more
europepmc   +1 more source

HIV-1 Proteins gp120 and Tat Promote Epithelial-Mesenchymal Transition and Invasiveness of HPV-Positive and HPV-Negative Neoplastic Genital and Oral Epithelial Cells. [PDF]

Microbiol Spectr, 2022
Lien K, Mayer W, Herrera R, Padilla NT, Cai X, Lin V, Pholcharoenchit R, Palefsky J, Tugizov SM.   +8 more
europepmc   +1 more source

Oral Nanomicelle‐Mediated Sequential Butyrate Production in the Intestine for Ulcerative Colitis and Immunosuppression Treatment

Advanced Science, EarlyView.
After oral administration, inodorous GLU‐BA self‐assembles into nanomicelles in aqueous environments to resist premature gastric adsorption. Upon reaching the intestine, endogenous esterases rapidly cleave the built‐in ester bonds in these nanomicelles to release BA and GLU, with GLU further metabolized by gut microbiota to gradually generate BA ...
Feifei Xin, Zhike Xie, Danyue Zhao, Lin Yang, Yiqun Wan, Zuwei Liu, Situ Xiong, Ying Zhang, Lei Feng, Hao Wan   +9 more
wiley   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

RvD1_{n-3 DPA} Downregulates the Transcription of Pro-Inflammatory Genes in Oral Epithelial Cells and Reverses Nuclear Translocation of Transcription Factor p65 after TNF-α Stimulation. [PDF]

Int J Mol Sci, 2022
Balta MG, Schreurs O, Halder R, Küntziger TM, Saetre F, Blix IJS, Baekkevold ES, Glaab E, Schenck K.   +8 more
europepmc   +1 more source

Vitamin D₃ Modulates Inflammatory and Antimicrobial Responses in Oral Epithelial Cells Exposed to Periodontitis-Associated Bacteria. [PDF]

Int J Mol Sci
Karaca F, Bloch S, Kendlbacher FL, Behm C, Schäffer C, Andrukhov O.   +5 more
europepmc   +1 more source

Transcriptome-wide m⁶A methylome analysis uncovered the changes of m⁶A modification in oral pre-malignant cells compared with normal oral epithelial cells. [PDF]

Front Oncol, 2022
Chen X, Chen L, Tang Y, He Y, Pan K, Yuan L, Xie W, Chen S, Zhao W, Yu D.   +9 more
europepmc   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source