Results 51 to 60 of about 7,425,496 (297)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The Effects of Oral Function Improving Exercise on the UWS, Oral function and OHIP in Elderly [PDF]

Journal of Korean Public Health Nursing, 2012
Purpose: The purpose of this study was to investigate the effects of oral exercise on oral function and quality of life among community-dwelling elders. Methods: This was a quasi-experimental study. Sixty four participants were recruited from the dental clinic of a public health center in G City, Gyeonggi-do.
Soon-Ok Yang, Geumhee Jeong, Shin-Jeong Kim, Kyongwon Kim, Seung Hee Lee, Sooyoung Saung, Sunghee Baik   +6 more
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Mineral trioxide aggregate induces osteoblastogenesis via Atf6

Bone Reports, 2015
Mineral trioxide aggregate (MTA) has been recommended for various uses in endodontics. To understand the effects of MTA on alveolar bone, we examined whether MTA induces osteoblastic differentiation using MC3T3-E1 cells.
Toyonobu Maeda, Atsuko Suzuki, Satoshi Yuzawa, Yuh Baba, Yuichi Kimura, Yasumasa Kato   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Lip muscle training improves obstructive sleep apnea and objective sleep: a case report [PDF]

Sleep Science
The present study assessed the potential of lip muscle training for improving sleep. A patient with heavy snoring, daytime sleepiness and dry mouth underwent lip muscle training.
Hiroshi Suzuki, Mayuko Yoshimiura, Yoshihiro Iwata, Sumito Oguchi, Misao Kawara, Chin-Moi Chow   +5 more
doaj   +1 more source

Location of mechanically-evoked referred sensations within the trigeminal region are not altered following a heterotopic painful stimulus

Scientific Reports, 2022
To investigate whether the location, area and frequency of referred sensations occurring during palpation of the masseter muscle can be influenced by application of a conditioning painful stimulus to the temporalis muscle.
Fernando G. Exposto, Miranda Huang, Talita Haasnoot, Michail Koutris, Frank Lobbezoo, Karina H. Bendixen, Peter Svensson   +6 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Evaluating GPT-4V’s performance in the Japanese national dental examination: A challenge explored

Journal of Dental Sciences
Background/purpose: Rapid advancements in AI technology have led to significant interest in its application across various fields, including medicine and dentistry.
Masaki Morishita, Hikaru Fukuda, Kosuke Muraoka, Taiji Nakamura, Masanari Hayashi, Izumi Yoshioka, Kentaro Ono, Shuji Awano   +7 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source