Results 61 to 70 of about 7,690,612 (280)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
“[This] I Know from My Grandfather”: The Battle for Admissibility of Indigenous Oral History as Proof of Tribal Land Claims [PDF]
, 2012 A major obstacle indigenous land claimants must face is the application of federal evidentiary rules, like the hearsay doctrine, which block the use of oral history to establish legal claims.
Babcock, Hope M.
core +2 more sources
Relationship Between Oral Health and Clinical Osteoporosis Among Hospitalized Patients with and Without Diabetes [PDF]
, 2020 Objective: Diabetes mellitus (DM) is associated with poor oral health and osteoporosis (OP). The aim of this study was to assess the relationship between OP, periodontal disease (PD), and other dental and health outcomes in a cohort of hospitalized ...
Allenback, Gayle +4 more
core +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The Development of Oral History in the United States: the evolution toward interdisciplinary
Tempo e Argumento, 2018 This article discusses the development of oral history in the United States and how this has led the field to becoming interdisciplinary in interesting and useful ways.
David king Dunaway
doaj +1 more source
, 2008 The chapter reviews three different approaches to biographical methods, the biographical interpretive method, oral history and narrative analysis. Each is outlined in turn, looking at distinguishing characteristics.
Bornat, Joanna
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Voicing New Identities. Two Case-Studies of Oral History and Displacement in WW2 and its Aftermath [PDF]
Close Encounters in War Journal, 2019 The current refugee crisis is unprecedented, and it prompts many questions on how to tackle the emergency and on the mechanisms of international humanitarian aid.
Simona Tobia
doaj