Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray+2 more
wiley +1 more source
Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review
Current evidence pinpoints that the variability in periodontitis traits in humans may be attributable to genetic factors. Different allelic variants can result in alterations in tissue structure, antibody responses and inflammatory mediators ...
Aniela Brodzikowska, Bartłomiej Górski
doaj +1 more source
A Computational Analysis of Oral Argument in the Supreme Court [PDF]
As the most public component of the Supreme Court's decision-making process, oral argument receives an out-sized share of attention in the popular media. Despite its prominence, however, the basic function and operation of oral argument as an institution remains poorly understood, as political scientists and legal scholars continue to debate even the ...
arxiv
An immunohistochemical study of the distribution of p 16 protein in oral mucosa in smokers, non-smokers and in frictional keratosis [PDF]
Objective: Our study aimed to characterize alteration in the immunohistochemical p16 expression in normal oral mucosa and non-neoplastic hyperproliferative disorders (i.e. frictional keratosis and mucosa from smokers). Study design: 43 specimen of oral
Kujan, Omar+2 more
core +1 more source
Effect of ruxolitinib on the oral mucosa of patients with steroid-refractory chronic Graft-versus-Host disease and oral involvement [PDF]
BACKGROUND: Chronic Graft-versus-Host Disease (cGVHD) can impact quality of life, especially in patients with oral involvement. Half of the patients with cGVHD do not respond to first-line therapy with corticosteroids and calcineurin inhibitors ...
Bellido, Mar+9 more
core +1 more source
Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics
This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold+2 more
wiley +1 more source
Photodynamic therapy in non-surgical treatment of periodontitis
Periodontitis is a chronic inflammation disease that, apart from caries, remains the main cause of tooth loss, that lead to a deterioration of the quality of life.
Adrian Maj+4 more
doaj +1 more source
DEMOGRAPHIC PROFILE OF ORAL LICHEN PLANUS PATIENTS IN THE BULGARIAN POPULATION. CLINICOPATHOLOGICAL CORRELATION IN THE DIAGNOSIS OF THE DISEASE [PDF]
Oral lichen planus (OLP) is a relatively common mucosal disease that mainly affects middle-aged women, yet the epidemiological characteristics of this condition in the Bulgarian population are poorly studied.
Maria Mutafchieva
doaj +1 more source
To improve treatment efficacy of gingival recessions (GR), chemical preparation of the exposed root surface was advocated. The aim of this study was to compare the additional influence of root biomodifications with 24% ethylenediaminetetraacetic acid ...
Bartłomiej Górski, Marcin Szerszeń
doaj +1 more source
N-alkylamides : from plant to brain [PDF]
Background: Plant N-alkylamides (NAAs) are bio-active compounds with a broad functional spectrum. In order to reach their pharmacodynamic targets, they have to overcome several barriers of the body in the absorption phase.
De Spiegeleer, Bart+6 more
core