Results 111 to 120 of about 86,974 (295)

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Potentially malignant disorders of the oral and oropharyngeal mucosa; present concepts of management

, 2009
In spite of tremendous progress in the field of molecular biology there is yet no single marker that reliably predicts malignant transformation of a potentially malignant disorder of the oral mucosa.
van der Waal, I., Waal, I. van der
core   +1 more source

Outcome of CO2 laser vaporization for oral potentially malignant disorders treatment [PDF]

, 2018
Oral cancer is a public health issue worldwide. Oral potentially malignant disorders (OMPDs) are lesions of the oral mucosa that are predisposed to malignant transformation. The mainstay of OMPDs treatment around the world is now the carbon dioxide (CO2)
ROSA, R. W., Fricain, Jean-Christophe, CLOITRE, A., Cloitre, Alexandra, A Cloitre, JC Fricain, Rosa, Rafael Weber, RW Rosa, FRICAIN, J. C., Rosa, Rafael W., Arrive, Elise, E Arrive   +11 more
core   +1 more source

Potentially malignant oral disorders

, 2023
Potencijalno maligni oralni poremećaji sva su stanja koja mogu prethoditi nastanku karcinoma usne šupljine. Tradicionalna podjela prema iz 1978. godine na premaligne lezije i premaligna stanja napuštena je 2005.
Bedalov, Lucija
core   +1 more source

Immunoglobulin a in oral potentially malignant disorders and oral squamous cell carcinoma

Journal of Medical Sciences, 2017
Introduction: Oral squamous cell carcinomas (OSCCs) are malignancies which develop predominantly from preexisting potentially malignant disorders. Immunoglobulin A (IgA) in saliva and serum is responsible for local immune response.
Vidya Ajila, Veena Shetty, Subhas Babu, Shruthi Hegde, Shama Rao   +4 more
doaj   +1 more source

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

8‐Oxoguanine Modified CircMTUS1 Drives PABPC1 Phase Separation to Promote Gastric Cancer Progression and Cisplatin Resistance via Autophagy

Advanced Science, EarlyView.
ABSTRACT Gastric cancer (GC) is a major global health concern, as its prevention and treatment remain significant challenges. The 8‐oxoguanine (o8G) modification of circRNAs, alongside their capacity to orchestrate liquid‐liquid phase separation (LLPS) and autophagy, plays a pivotal role in driving tumor progression and determining therapeutic outcomes.
Lei Peng, Lurong Li, Zhenghui Zhu, Chenyang Li, Huaiming Sang, Guoxin Zhang, Xuan Li, Yini Dang, Yuanyuan Li   +8 more
wiley   +1 more source

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

The Need to Improve the Medical Subject Headings (MeSH) and the Excerpta Medica Tree (EMTREE) Thesauri to Perform Systematic Review on Oral Potentially Malignant Disorders

Background Despite recent advancements in the understanding and classification of oral potentially malignant disorders (OPMD), their terminology remains inconsistent and heterogeneous throughout the scientific literature, thus affecting evidence-based ...
Caponio, Vito Carlo Alberto, Amaral Mendes, Rui, López-Pintor Muñoz, Rosa María, Musella, Gennaro, Pérez-Sayáns, Mario, Lo Muzio, Lorenzo   +5 more
core   +1 more source

Predisposing Factors and Clinico-Pathological Presentation of Malignant Lesions of the Oro-Facial Region Among Patients Attending the Muhimbili National Hospital in Dar-es-Salaam, Tanzania [PDF]

, 2011
The oro-facial region is made up of a complex anatomical relationship of structures of which may be a source of development of malignant lesions. Often, patients present at the oral and maxillofacial unit of Muhimbili National Hospital with a variety of ...
Berege, Gemma Z
core