Results 101 to 110 of about 329,030 (268)

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Keratoconus and quality of life: an updated comprehensive review

BMC Ophthalmology
Keratoconus (KCN), a progressive ectatic corneal disorder, significantly impacts vision-related quality of life (VRQoL) beyond reduced visual acuity. This review aims to comprehensively examine the impact of keratoconus on patients’ quality of life (QoL),
Seyed Mohsen Rafizadeh, Ghazal Ghochani, Foroozan Narooie-Noori, Masoud Khorrami-Nejad   +3 more
doaj   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Reply to “Comment on ‘No evidence for orbital loop currents in charge-ordered YBa2Cu3O6+x from polarized neutron diffraction”' [PDF]

, 2018
T. P. Croft, E. Blackburn, J. Kulda, Ruixing Liang, D. A. Bonn, W. N. Hardy, S. M. Hayden   +6 more
openalex   +1 more source

Multi‐satellite autonomous orbit determination by game‐theoretic optimization in space service volume

, 2021
Kui Lin, Xingqun Zhan, Rong Yang, Cheng Chi, Jin Chang   +4 more
openalex   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Coulomb-free and Coulomb-distorted recolliding quantum orbits in photoelectron holography

, 2018
Andrew Maxwell, C. Figueira de Morisson Faria   +1 more
openalex   +1 more source

Retrieval of molecular alignment and identification of multiple-orbital contribution by using polarized high harmonics from aligned N₂ molecules

, 2020
Xiaoli Guo, Cheng Jin, Ziqiang He, Jinping Yao, Xiaoxin Zhou, Ya Cheng   +5 more
openalex   +1 more source

Surgical Rehabilitation of a Continuous Orbital and Maxillary Defect from Rhino-Orbital Mucormycosis Utilising Digital Technology - A Case Report

, 2023
Manu Rathee, Sujata Chahal, Maqbul Alam, Sandeep Singh, S. Divakar   +4 more
openalex   +1 more source