Results 101 to 110 of about 907,233 (318)

Solitary eyelid neurofibroma presenting as tarsal cyst: Report of a case and review of literature

American Journal of Ophthalmology Case Reports, 2018
Purpose: To report a rare case of solitary eyelid neurofiboma presenting as tarsal cyst. Observation: A 64 year old male, presented with a painless, non progressive swelling in the right upper eye lid.
Nisar Sonam Poonam, Md Shahid Alam, Dipankar Das, Jyotirmay Biswas   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

The on-orbit performance of the Orbiting Carbon Observatory-2 (OCO-2) instrument and its radiometrically calibrated products

, 2016
. The Orbiting Carbon Observatory-2 (OCO-2) carries and points a three-channel imaging grating spectrometer designed to collect high-resolution, co-boresighted spectra of reflected sunlight within the molecular oxygen (O2) A-band at 0.765 microns and the
D. Crisp
semanticscholar   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Carotid cavernous fistula masquerading as delayed suprachoroidal hemorrhage after trabeculectomy

GMS Ophthalmology Cases, 2017
Objective: Carotid cavernous fistulae (CCFs) are abnormal communications between the cavernous sinus and the carotid arterial system. Based on the etiology, CCFs can be traumatic, spontaneous and rarely iatrogenic.
Jain, Mukesh, Alam, Md. Shahid, Mukherjee, Bipasha, Raman, Rajiv   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Enhanced spin–orbit torques by oxygen incorporation in tungsten films

Nature Communications, 2016
The origin of spin–orbit torques, which are generated by the conversion of charge-to-spin currents in non-magnetic materials, is of considerable debate. One of the most interesting materials is tungsten, for which large spin–orbit torques have been found
Kai-Uwe Demasius, Timothy Phung, Weifeng Zhang, Brian P. Hughes, See-Hun Yang, A. Kellock, W. Han, A. Pushp, S. Parkin   +8 more
semanticscholar   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

An axiomatic system engineering design method based on NSGA-II algorithm applied to complex systems

Scientific Reports
This study proposes an integrated framework that combines Axiomatic Design with Model-Based Systems Engineering, incorporating NSGA-II as an intelligent optimization engine. The framework constructs a multi-level traceability matrix linking requirements,
Xiaoqian Zhang, Qinghai Zhang, Qingjian Zhao, Shuang Zhao, Yanan Zhao, Yang Guo, Zhengxu Zhao, Liqiang Song   +7 more
doaj   +1 more source