Molecular Oncology, EarlyView.Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy +12 more
wiley +1 more source
On orbital variety closures in sl(n). II. Descendants of a Richardson orbital variety [PDF]
Journal of Algebra 271, 2004, pp 698-724, 2003 For a semisimple Lie algebra g the orbit method attempts to assign representations of g to (coadjoint) orbits in g*. Orbital varieties are particular Lagrangian subvarieties of such orbits leading to highest weight representations of g. In sl(n) orbital varieties are described by Young tableaux.
arxiv
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
A Case of Pulsating Tumour of the Left Orbit, Consequent upon a Fracture of the Base of the Skull, Cured by Ligature of the Left Common Carotid Artery Subsequently to Injection of Perchloride of Iron after Digital Compression and other Means of Treatment Had Failed. With Remarks and An Appendix Containing a ChronologicalRésuméof Recorded Cases of Intra-Orbital Aneurism [PDF]
, 1875 Walter Rivington
openalex +1 more source
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
On Sir Isaac Newton's Method of Determining the Parabolic Orbit of a Comet [PDF]
, 1925 A. N. Kriloff
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Molecular Oncology, EarlyView.The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita +1 more
wiley +1 more source
ROYAL ALBERT EDWARD INFIRMARY, WIGAN. FRACTURE OF THE ORBITAL PLATE OF FRONTAL BONE, AND PERFORARION INTO LATERAL VENTRICLE OF BRAIN ; DEATH ; NECROPSY; REMARKS [PDF]
, 1884 John M. Jackson
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Molecular Oncology, EarlyView.In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen +17 more
wiley +1 more source
Solitary eyelid neurofibroma presenting as tarsal cyst: Report of a case and review of literature
American Journal of Ophthalmology Case Reports, 2018 Purpose: To report a rare case of solitary eyelid neurofiboma presenting as tarsal cyst. Observation: A 64 year old male, presented with a painless, non progressive swelling in the right upper eye lid.
Nisar Sonam Poonam +3 more
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