Results 91 to 100 of about 17,572 (266)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Ground-Based Testing of In-Orbit Interactions Under Scale and Time-Delay Limitations
IEEE AccessOn-ground facilities provide opportunities for robot-assisted emulation of on-orbit space operations; however, they present unique challenges, including accurately scaling satellite dynamics for laboratory environments, ensuring stable motion-execution ...
Mohatashem Reyaz Makhdoomi +6 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Excitation of coupled spin-orbit dynamics in cobalt oxide by femtosecond laser pulses. [PDF]
Nat Commun, 2017 Satoh T +9 more
europepmc +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Modeling and Optimization of Trans-lunar Orbit for Lunar Polar Station
Kongzhi Yu Xinxi Jishu, 2019 Lunar polar station is one of the effective ways for private lunar tourism and lunar surface global access mission in the future, the station resupply mission requires a modeling and optimization method for a two-impulse trans-lunar orbit with high ...
HE Boyong
doaj
Ga-based MPC for satellite’s attitude and orbit control
Discover Applied SciencesThis article addresses the challenge of controlling both attitude and orbit in satellites using an integrated approach. Traditional designs typically employ separate systems for orbit control, such as thrusters, and attitude control, such as reaction ...
Prasitthichai Naronglerdrit +1 more
doaj +1 more source
LaboratOry for the Behavior of the SloT Region: a small mission doing big radiation science
Frontiers in Astronomy and Space SciencesThis paper outlines the science and basic design choices associated with a mission concept study known as the LaboratOry for the Behavior of the SloT Region (LOBSTR).
Rachael Filwett +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
International Journal of Aerospace EngineeringThis paper analyzes the root causes of attitude-orbit coupling effects of spacecraft proximity relative motion in space precision collaborative tasks from three aspects: mathematical representation, physical definition, and engineering applications.
An Hao +5 more
doaj +1 more source