Results 51 to 60 of about 484,486 (336)

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Orbit Determination via a Deeply- Coupled UKF/GNSS Filter [PDF]

open access: yesفصلنامه علوم و فناوری فضایی, 2016
This paper is dedicated to determining the orbit of a satellite by using Unscented Kalman Filter (UKF), in which, a GNSS is used as the observation sensor.
MohammadAli Amiri Atashgah   +2 more
doaj  

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Unraveling the dynamics of magnetization in topological insulator-ferromagnet heterostructures via spin-orbit torque

open access: yesnpj Spintronics
Spin–orbit coupling is a relativistic effect coupling the orbital angular momentum with the spin, which determines the physical properties of condensed matter.
Taekoo Oh, Naoto Nagaosa
doaj   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

Resonant periodic orbits in the exoplanetary systems [PDF]

open access: yesAstrophysics and Space Science, Volume 349, Issue 2, pp.657-676 (2014), 2013
The planetary dynamics of $4/3$, $3/2$, $5/2$, $3/1$ and $4/1$ mean motion resonances is studied by using the model of the general three body problem in a rotating frame and by determining families of periodic orbits for each resonance. Both planar and spatial cases are examined.
arxiv   +1 more source

A generalized super-twisting algorithm-based adaptive fixed-time controller for spacecraft pose tracking

open access: yesOpen Astronomy
A generalized super-twisting second-order sliding mode adaptive fixed-time control law, which is used for spacecraft pose tracking in the presence of internal and external uncertainties, is proposed.
Gong Kejie   +5 more
doaj   +1 more source

Piecewise expanding maps: combinatorics, dynamics and representation of rational numbers

open access: yesESAIM: Proceedings and Surveys, 2014
We establish combinatorial properties of the dynamics of piecewise increasing, continuous, expanding maps of the interval such as description of periodic and pre-periodic points, primitiveness of truncated itineraries and length of ...
Serpa Cristina, Buescu Jorge
doaj   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

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