Results 51 to 60 of about 20,106 (266)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Spin-Orbit Angles: Reflections of Dynamics in Systems

open access: yesEPJ Web of Conferences, 2011
We will present our campaign to estimate the projected spin-orbit angle for transiting hot Jupiters, measured by observing the Rossiter-McLaughlin effect. Combining our efforts to those of other teams we show what the current distribution in projected spin-
Cameron A.C., Queloz D., Triaud A.H.M.J.
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Constructing the Second Order Poincaré Map Based on the Hopf-Zero Unfolding Method

open access: yesAbstract and Applied Analysis, 2013
We investigate the Shilnikov sense homoclinicity in a 3D system and consider the dynamical behaviors in vicinity of the principal homoclinic orbit emerging from a third order simplified system.
Gen Ge, Wang Wei
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Dynamical behaviour of a compound elastic pendulum

open access: yesMATEC Web of Conferences, 2018
The aim of the paper is a comprehensive study of the compound elastic pendulum (CEP) with two degrees of freedom to point out the main complex (chaotic) dynamics that it can exhibit.
Nikolov Svetoslav, Zaharieva Daniela
doaj   +1 more source

Orbit/CLASP is required for germline cyst formation through its developmental control of fusomes and ring canals in Drosophila males.

open access: yesPLoS ONE, 2013
Orbit, a Drosophila ortholog of microtubule plus-end enriched protein CLASP, plays an important role in many developmental processes involved in microtubule dynamics.
Chie Miyauchi   +4 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

open access: yesFEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom   +3 more
wiley   +1 more source

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