Results 141 to 150 of about 11,324,813 (340)

HNRNPD Induces Radioresistance in Nasopharyngeal Carcinoma by Sequestering GRAMD4 mRNA in Stress Granules

Advanced Science, EarlyView.
HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li, Tong Xiang, Yuanyuan Liu, Desheng Weng, Jingjing Zhao, Hao Chen, Yan Tang, Songzuo Xie, Hao Zhang, Jun Luo, Xinyi Yang, Qiuzhong Pan, Muping Di, Jianchuan Xia   +13 more
wiley   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Influencing factors for pediatric eye disorders and health related quality of life: a cross-sectional study in Shanghai, China

Frontiers in Medicine
BackgroundMyopia, strabismus, and ptosis are common pediatric eye diseases, which have a negative impact on children and adolescents in terms of visual function, mental health, and health-related quality of life (HRQoL).
Qin Shu, Qin Shu, Zhongzhou Xiao, Xinwei Peng, Xiaoyi Liang, Xiaoyi Liang, Moxin Chen, Moxin Chen, Zhuoran Tao, Zhuoran Tao, Qianwen Liu, Qianwen Liu, Yonglin Guo, Yonglin Guo, Xuefeng Yang, Xuefeng Yang, Wanqin Nie, Wanqin Nie, Ruiyao Chen, Liya Yang, Jin Li, Jin Li, Jie Xu, Lin Li, Lin Li   +24 more
doaj   +1 more source

Dual‐Targeting Cuproptosis and Mitophagy via a Flavopiridol‐Copper Nanoplatform Potentiates Immunotherapy Against Uveal Melanoma

Advanced Science, EarlyView.
This study develops a GSH‐responsive nanoplatform, NP@Fla‐Cu, to co‐activate cuproptosis and excessive mitophagy in uveal melanoma. The nanoplatform enhances tumor‐specific copper delivery, depletes antioxidant defenses, and remodels the tumor immune microenvironment.
Hong Ren, Zhihong Deng, Sheng Lu, Jing Zhang, Wenbin Liu, Jia Tan   +5 more
wiley   +1 more source

Acute Bilateral Ophthalmoplegias [PDF]

, 1977
Bilateral ophthalmoplegia is that condition of weakness or paralysis involving one or more ocular muscles in each eye. Its sudden appearance due to an acute ocular myopathy is indeed unusual. Swash reported a single patient with acute necrotizing orbital
Selhorst, John B.
core   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Periocular skin “tattooing” caused by gel pen pigment mistaken for periorbital bruising: a case of missed diagnosis of traumatic intraorbital pen core foreign body [PDF]

International Journal of Ophthalmology
Chao Xiong, Zhang-Jun Ren, Xue-Mei Li, Jin-Hai Yu, Yue Li, Yun-Xiu Chen, Qi Jin, Ze-Xi Sang, Si-Yi Wang, An-An Wang, Pu-Ying Gan, Qi-Hua Xu, Yao-Hua Wang, Hong-Fei Liao   +13 more
doaj   +1 more source

Synergistic Sunlight‐Activated Photodynamic and Near‐Infrared‐Induced Mild Photothermal Therapy for Infected Wound Healing Using Functionalized Nano‐Bi2WO6 Composites

Advanced Science, EarlyView.
This work proposes a multifunctional Bi2WO6:Yb,Er@CuS@CS nanocomposite that integrates photodynamic therapy (PDT), near‐infrared‐triggered photothermal therapy (PTT), and Cu2+ release for infected wound repair. The nanocomposite demonstrates enhanced antibacterial efficacy via combined PDT, PTT, and Cu2+ release, effective immunomodulatory by mild ...
Yihao Sun, Liangrui He, Zhijun Shen, Yuxin Zhang, Yizhang Tang, Xujiang Yu, Jisi Zheng, Moran Huang, Wanwan Li, Lei Wang   +9 more
wiley   +1 more source

Progress in 3D Printing Applications for the Management of Orbital Disorders: A Systematic Review

Bioengineering
Introduction: 3D printing technology has gained considerable interest in the domain of orbital illnesses owing to its capacity to transform diagnosis, surgery planning, and treatment.
Luca Michelutti, Alessandro Tel, Massimo Robiony, Salvatore Sembronio, Riccardo Nocini, Edoardo Agosti, Tamara Ius, Caterina Gagliano, Marco Zeppieri   +8 more
doaj   +1 more source

On the First Anthropic Argument in Astrobiology

, 2003
We consider the little-known anthropic argument of Fontenelle dealing with the nature of cometary orbits, given a year before the publication of Newton's Principia.
Cirkovic, Milan M.
core   +1 more source