Results 181 to 190 of about 599,612 (252)

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

Variation in blood culture testing in children hospitalized with three common infections

Journal of Hospital Medicine, EarlyView.
Abstract Background Routine blood culture (BCx) testing in uncomplicated community‐acquired pneumonia (CAP), skin and soft tissue infections (SSTI), and urinary tract infections (UTI) has demonstrated low clinical utility. Objectives To evaluate hospital‐level BCx testing trends and their association with clinical outcomes for children hospitalized ...
Smit Shah, Jennifer L. Goldman, Matt Hall, John R. Stephens, Jillian M. Cotter, Samantha A. House, Matthew J. Molloy, Michelle Polich, Michael J. Steiner, Michael J. Tchou, Ronald J. Teufel II, Irma T. Ugalde, Andrew G. Yu, Jessica L. Markham   +13 more
wiley   +1 more source

Orbital - Vol. 6 No. 2 - April-June 2014 [PDF]

, 2013
Production, Orbital, Orbital Production
core  

Sharing Good News at Work to Collaborate and to Self‐Enhance: A Motivational and Reputational Perspective on Workplace Interpersonal Capitalization

Journal of Organizational Behavior, EarlyView.
ABSTRACT Employees routinely experience work‐related positive events. In the wake of these events, employees sometimes share the good news with coworkers—a phenomenon known as workplace interpersonal capitalization. Research shows that such capitalization matters for how employees feel and act.
Trevor Watkins, Ji Koung Kim, Anthony C. Klotz, Satish Krishnan   +3 more
wiley   +1 more source

Covering Up for Coworkers: A Scale Development and Empirical Examination of Relational Cover‐Up Behavior

Journal of Organizational Behavior, EarlyView.
ABSTRACT Why do employees conceal their coworkers' unethical behavior and who is most likely to do so? To address these questions, we begin by developing and validating a psychometrically robust measure of relational cover‐up behavior (Study 1). Using a two‐wave study (N = 475), we then test the argument that employees may experience an identity threat
Jenny H. Wang, Annika Hillebrandt, Laurie J. Barclay   +2 more
wiley   +1 more source

Orbital - Vol. 6 No. 1 - January-March 2014 [PDF]

, 2014
Production, Orbital, Orbital Production
core  

Gastroprotective effects of Sapodilla fruit powder against ethanol‐induced gastric injury in Sprague–Dawley rats: In silico prediction and in vivo validation

JSFA reports, EarlyView.
Abstract Background Gastrointestinal disorders are rapidly increasing worldwide due to the disturbance of mucosal defenses. Manilkara zapota possesses significant therapeutic attributes to improve individual well‐being. Objectives The current study was conducted to evaluate the antioxidant activity, phytochemical characterization, and in silico and in ...
Ayesha Siddiqa, Adnan Amjad, Muhammad Maaz, Ahmad Mujtaba Noman, Tadesse Fenta Yehuala, Shehnshah Zafar, Syeda Khimar Zahra Kazmi, Duaa Tariq   +7 more
wiley   +1 more source

Orbital - Vol. 4 No. 4 - October-December 2012 [PDF]

, 2013
Production, Orbital, Orbital Production
core  

Mechanism of RNA‐Binding Protein ELAVL1 in Promoting Th2 Cell Differentiation Through Stabilizing CPA3 mRNA in Allergic Rhinitis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to elucidate the role of the RNA‐binding protein embryonic lethality abnormal vision‐like protein 1 (ELAVL1) in the pathogenesis of allergic rhinitis (AR), specifically by investigating its potential to promote T helper 2 (Th2) cell differentiation by regulating the stability of carboxypeptidase A3 (CPA3) mRNA.
Meng‐Ya Liu, Hong‐Bing Yao, Cheng Chen   +2 more
wiley   +1 more source

Bilateral Ophthalmoplegia After Neoadjuvant Pembrolizumab for Oral Cavity Squamous Cell Carcinoma

The Laryngoscope, EarlyView.
The role of immune checkpoint inhibition (ICI) therapy in the treatment of head and neck squamous cell carcinoma (HNSCC) is expanding with increased utilization of neoadjuvant and adjuvant pembrolizumab in the setting of locally advanced disease. This report describes the presentation and management of the first known case of pembrolizumab‐induced ...
Leonard E. Estephan, Peter Jacoby, David M. Cognetti, Steven A. Manobianco   +3 more
wiley   +1 more source