Next‐generation proteomics improves lung cancer risk prediction
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Trajectory classification through Freeman's curve encoding and entropic analysis. [PDF]
Peña-Mendieta R +5 more
europepmc +1 more source
Anomalous High-Energy Waterfall-Like Electronic Structure in 5d Transition Metal Oxide Sr2IrO4 with a Strong Spin-Orbit Coupling [PDF]
Yan Liu +23 more
openalex +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Satellite megaconstellations will threaten space-based astronomy. [PDF]
Borlaff AS, Marcum PM, Howell SB.
europepmc +1 more source
A simple derivation of the two force laws for elliptic orbits from\n Proposition 6 in Newton's Principia [PDF]
Michael Nauenberg
openalex +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Post-surgical Comparison of Volumetric Analysis in Orbital Fractures with Conventional and Advanced Management. [PDF]
González LV +4 more
europepmc +1 more source
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Two-dimensional positioning of the crab pulsar with avoidance of non-sensitive direction. [PDF]
Chen J, Zhang H, Liu J, Ma X, Ning X.
europepmc +1 more source

