Results 211 to 220 of about 572,560 (281)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

GRPhIN: graphlet characterization of regulatory and physical interaction networks. [PDF]

Bioinform Adv
Barelvi A, Anderson O, Ritz A.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

OrbiTox: a visualization platform for NAMs and read-across exploration of multi-domain data. [PDF]

Front Pharmacol
Ross A, Gombar V, Sedykh A, Green AJ, Borrel A, Kidd B, Phillips J, Shah M, Phadke D, Mav D, Balik-Meisner M, Howard B, Shah R, Kleinstreuer NC, Casey WM.   +14 more
europepmc   +1 more source

I. Elements of the Orbit of the Binary Star   Virginis [PDF]

J. R. Hind
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Case Reports of Teprotumumab as Treatment for Monoclonal Antibody-Induced Thyroid Orbitopathy. [PDF]

Reports (MDPI)
Moon J, Duncan N, Yorio J, Meltzer E, Aung MH.   +4 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Ocular Translation Due to Gravitational Acceleration. [PDF]

Invest Ophthalmol Vis Sci
Demer JL, Clark RA.
europepmc   +1 more source

Orbital implants and prostheses: postoperative computed tomographic appearance.

, 1985
M. Elon Gale, Melanie Vincent, Francis C. Sutula   +2 more
openalex   +1 more source