Results 221 to 230 of about 572,560 (281)

Orbital angular momentum of an arbitrary axisymmetric light field after passing through an off-axis spiral phase plate

, 2018
Victor V. Kotlyar, A. A. Kovalev
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Functional Anatomy of Ocular Counter-Rolling in Superior Oblique Palsy. [PDF]

Invest Ophthalmol Vis Sci
Demer JL, Clark RA.
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Abrupt structural transition in exotic molybdenum isotopes unveils an isospin-symmetric island of inversion. [PDF]

Nat Commun
Ha J, Recchia F, Lenzi SM, Iwasaki H, Dao DD, Nowacki F, Revel A, Aguilera P, de Angelis G, Ash J, Bazin D, Bentley MA, Biswas S, Carollo S, Cortes ML, Elder R, Escudeiro R, Farris P, Gade A, Ginter T, Grinder M, Li J, Napoli DR, Noji S, Pereira J, Pigliapoco S, Pompermaier A, Poves A, Rezynkina K, Sanchez A, Wadsworth R, Weisshaar D.   +31 more
europepmc   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Orbital masses: a review of CT imaging characteristics. [PDF]

Front Ophthalmol (Lausanne)
Levanon E, Greenberg G, Lustig-Barzelay Y, Landau-Prat D, Ben Simon GJ.   +4 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Asymmetric thyroid eye disease. [PDF]

Saudi J Ophthalmol
Rana K, Yong LSS, Garg D, Patel S, Slattery J, Davis G, Chan WO, Selva D.   +7 more
europepmc   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

FEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić, Darija Putar, Lucija Mijanović, Igor Weber   +3 more
wiley   +1 more source