Results 21 to 30 of about 38,512 (206)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Non-Cooperative Target Ranging Based on High-Orbit Single-Star Temporal–Spatial Characteristics

Applied Sciences
A visible light camera payload with star-sensitive functionality was installed to measure the distance between a non-cooperative target satellite and a high-orbit satellite. The rotation matrix was used to calculate the pointing vector from the center of
Derui Zhang, Hao Wang, Qing Zhao
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Sensitivity Analysis of Chaotic Systems using Unstable Periodic Orbits

, 2018
A well-behaved adjoint sensitivity technique for chaotic dynamical systems is presented. The method arises from the specialisation of established variational techniques to the unstable periodic orbits of the system.
Lasagna, Davide
core   +1 more source

Corotating and irrotational binary black holes in quasi-circular orbits [PDF]

, 2001
A complete formalism for constructing initial data representing black-hole binaries in quasi-equilibrium is developed. Radiation reaction prohibits, in general, true equilibrium binary configurations. However, when the timescale for orbital decay is much
A. Ashtekar, A. Buonanno, A. Komar, A. Lichnerowicz, A.D. Kulkarni, D.M. Eardley, E. Gourgoulhon, E. Gourgoulhon, G.B. Cook, G.B. Cook, G.B. Cook, G.B. Cook, Gregory B. Cook, H. Tagoshi, H.P. Pfeiffer, J. Thornburg, J.B. Hartle, J.M. Bowen, J.M. Bowen, J.P. Ostriker, J.W. York, Jr., J.W. York, Jr., J.W. York, Jr., J.W. York, Jr., K. Alvi, K. Uryū, K. Uryū, L. Smarr, L.E. Kidder, L.E. Kidder, P. Grandclément, P. Marronetti, P. Marronetti, P. Marronetti, R. Beig, R.A. Matzner, S. Bonazzola, S. Bonazzola, S. Brandt, T. Damour, T.W. Baumgarte, T.W. Baumgarte, T.W. Baumgarte, T.W. Baumgarte   +43 more
core   +2 more sources

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Dynamics of Black Hole Pairs I: Periodic Tables

, 2008
Although the orbits of comparable mass, spinning black holes seem to defy simple decoding, we find a means to decipher all such orbits. The dynamics is complicated by extreme perihelion precession compounded by spin-induced precession.
H. Poincaré, Janna Levin, R. Grossman, Rebecca Grossman   +3 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source