Results 31 to 40 of about 38,512 (206)

Detecting chaos, determining the dimensions of tori and predicting slow diffusion in Fermi--Pasta--Ulam lattices by the Generalized Alignment Index method

, 2008
The recently introduced GALI method is used for rapidly detecting chaos, determining the dimensionality of regular motion and predicting slow diffusion in multi--dimensional Hamiltonian systems. We propose an efficient computation of the GALI$_k$ indices,
Antonopoulos, Chris, Bountis, Tassos, Skokos, Charalampos   +2 more
core   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Analytic orbit propagation for transiting circumbinary planets

, 2015
The herein presented analytical framework fully describes the motion of coplanar systems consisting of a stellar binary and a planet orbiting both stars on orbital as well as secular timescales.
Eggl, Siegfried, Georgakarakos, Nikolaos
core   +2 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

On the origin of the B-stars in the Galactic center

, 2014
We present a new directly-observable statistic which uses sky position and proper motion of stars near the Galactic center massive black hole to identify populations with high orbital eccentricities. It is most useful for stars with large orbital periods
Genzel, Reinhard, Gillessen, Stefan, Levin, Yuri, Madigan, Ann-Marie, Perets, Hagai B., Pfuhl, Oliver   +5 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Second moment of the Husimi distribution as a measure of complexity of quantum states

, 2001
We propose the second moment of the Husimi distribution as a measure of complexity of quantum states. The inverse of this quantity represents the effective volume in phase space occupied by the Husimi distribution, and has a good correspondence with ...
A. Boros, A. Wehrl, A. Wehrl, Ayumu Sugita, B. Eckhardt, E. J. Heller, E. J. Heller, H. Aiba, H.-D. Meyer, Hirokazu Aiba, K. Husimi, K. Takahashi, M. V. Berry, O. Bohigas, Th. Zimmermann   +14 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

A new perspective on the irregular satellites of Saturn - II Dynamical and physical origin

, 2009
The origin of the irregular satellites of the giant planets has been long debated since their discovery. Their dynamical features argue against an in-situ formation suggesting they are captured bodies, yet there is no global consensus on the physical ...
Benz, Buratti, Colombo, D. Turrini, Delsanti, F. Marzari, F. Tosi, Giese, Gomes, Grav, Grav, Jewitt, Morbidelli, Nesvorny, Pierazzo, Porco, Schmidt, Sheppard, Tsiganis, Turrini, Zappalá, Zappalá   +21 more
core   +1 more source