Results 141 to 150 of about 59,394 (312)

eQTL Meta‐Analysis Reveals Conserved and Population‐Specific Regulatory Variation Underlying Nutritional Trait Evolution and Domestication in Tomato

open access: yesAdvanced Science, EarlyView.
A comprehensive meta‐analysis of expression quantitative trait loci (eQTLs) across five diverse tomato populations reveals a high‐resolution atlas of transcriptional regulation and uncovers conserved and population‐specific regulatory architectures underlying fruit nutritional quality traits, including flavonoids, sugars, organic acids, carotenoids ...
Jiantao Zhao   +14 more
wiley   +1 more source

A spring session concert by the Chamber Orchestra, June 17, 1975

open access: yes, 2016
Recorded during a live performance at Oakland Recital Hall, Western Michigan University, Kalamazoo, Michigan, June 17, 1975, program no. 299 of the Department of Music’s 1974-1975 season.University Chamber Orchestra, Herbert Butler, conductor ; Steven ...
Western Michigan University. Chamber Orchestra
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Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

open access: yesAdvanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao   +12 more
wiley   +1 more source

Western String Chamber Orchestra, April 2, 1995

open access: yes, 2016
Recorded during a live performance at Dalton Center Recital Hall, Western Michigan University, Kalamazoo, Michigan, April 2, 1995, 5:00 p.m., the 396th concert of the School of Music’s 1994-1995 season.Western String Chamber Orchestra, Bruce Uchimura ...
Western String Chamber Orchestra
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Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

open access: yesAdvanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei   +11 more
wiley   +1 more source

Toledo Symphony Orchestra season of 1921-22, special twilight concert for benefit maintenance fund of orchestra, April 23, 1922

open access: yes
Program of the Toledo Symphony Orchestra, Toledo, Ohio, on April 23, 1922.
Toledo Symphony Orchestra
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Symphony no. 5 for double orchestra

open access: yes, 2015
Side A. Symphony no. 5 for double orchestra / Hong Kong Philharmonic, conductor Chan Wing Wah (25:52) -- Side B. Symphony no. 4 : "Te Deum" for soprano, tenor, choir & orchestra / Hong Kong Oratorio Society, Hong Kong Sinfonietta (31:46).Chan Wing-Wah ...

core  

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

open access: yesAdvanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi   +8 more
wiley   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

open access: yesAdvanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao   +7 more
wiley   +1 more source

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