Results 201 to 210 of about 59,394 (312)

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Symphony of Digestion: Coordinated Host-Microbiome Enzymatic Interplay in Gut Ecosystem. [PDF]

Biomolecules
Lushchak VI.
europepmc   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Orchestra: an open service architecture for risk management

, 2008
Lauzán, José Fernando Esteban, Vowles, Graham, Smith, I., Lucchi, Roberto, ORCHESTRA Consortium, Kunde, Simone, Schimak, Gerald, Dewey, N.K., Millot, Michel, Sabeur, Zoheir, Usländer, Thomas, Parker, Chris, Overton, David, Lutz, Michael, Ostlaender, Nicole, Douglas, John, Friis-Christensen, Anders   +16 more
core  

Toledo Symphony Orchestra season of 1921-22, third symphony program, January 20, 1921

Third program of the Toledo Symphony Orchestra, Toledo, Ohio, on January 20, 1922. Performance was at the Scott High School Auditorium.
Toledo Symphony Orchestra
core  

The sound of neural silence. [PDF]

Elife
Tjahjono N, Wang YS, Tian L.
europepmc   +1 more source

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, EarlyView.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

Beyond Autonomic Modulation: Baroreflex Activation Therapy and the Neuroimmune Axis in HFrEF. [PDF]

JACC Case Rep
Nenadic I, Fudim M.
europepmc   +1 more source

Microglia‐Targeted Biomimetic Tetrahedral Framework Nucleic Acid Nanovesicles for Synergistic Treatment of Sepsis‐Associated Encephalopathy

Advanced Science, EarlyView.
Sepsis‐associated encephalopathy (SAE) lacks effective therapies. We developed ME@FDsi, a biomimetic nanodrug using a tetrahedral framework nucleic acid to deliver disulfiram and siTNFα. It crosses the blood‐brain barrier, targets M1 microglia, inhibits pyroptosis and inflammation, and scavenges ROS.
Huimin Shi, Qiuxia Gao, Wenying Wang, Bin Li, Yukun Chen, Zhijun Yao, Yujie Li, Junrui Li, Na Li, Gong Gu, Zhimin Hou, Mengyuan Yang, Ruilin Zhang, Hongju Yang, Yuhui Liao, Hongyi Lei   +15 more
wiley   +1 more source

A Baton for Karaoke Intertwined with The Blade of The Surgeon. [PDF]

Arch Plast Surg
Hong JP, Innocenti M, Hallock GG.
europepmc   +1 more source