Results 31 to 40 of about 12,428 (228)

Impact of infectious complications in the overall structure of urethroplasty complications, treatment and antibiotic prophylaxis: a systematic review

Вестник урологии, 2023
Introduction. Urethroplasty is a urological operation that is widely used in the management of urethral stricture (US). However, postoperative complications are relatively common in this procedure. In their structure, infection takes the leading position
Yu. L. Naboka, E. M. Kotieva, V. M. Kotieva, M. I. Kogan   +3 more
doaj   +1 more source

Gasdermin D in macrophages drives orchitis by regulating inflammation and antigen presentation processes

EMBO Molecular Medicine
Inflammation in the testes induced by infection and autoimmunity contributes significantly to male infertility, a public health issue. Current therapies using antibiotics and broad-spectrum anti-inflammatory drugs are ineffective against non-bacterial ...
Chunmei Ma, Jiajia Huang, Yuying Jiang, Lu Liu, Na Wang, Shaoqiong Huang, Honghui Li, Xiangyu Zhang, Shuang Wen, Bingwei Wang, Shuo Yang   +10 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

SPARK: A webserver for comprehensive search and analysis of testicular single‐cell transcriptomic data covering full lifecycle and pathology

iMetaOmics, EarlyView.
SPARK is an interactive platform hosting 189,232 human testicular single‐cell transcriptomes across normal and infertile conditions. It enables automated, code‐free analysis and visualization, providing a powerful resource to explore cellular and molecular dynamics in male reproduction and infertility.
Lina Cui, Xiaojian Lu, Hui Cai, Ziyan Zhuang, Yifei Guo, Qiaoling Jiang, Zhe Zhang, Hui Jiang, Xiaoyan Wang, Jingtao Guo   +9 more
wiley   +1 more source

Immunoregulation in the testis and its implication in fertility and infections

Exploration of Immunology, 2021
The testis is designated as one of the immune previleged sites in the body and harbours a unique immunoregulatory environment, which is important for preventing an immune response against sperm antigens which otherwise are recognized as “foreign” by the ...
Kushaan Khambata, Deepak N. Modi, Satish K. Gupta   +2 more
doaj   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Maternal, childhood and adolescent influences on Leydig cell functional capacity and circulating INSL3 concentration in young adults: Importance of childhood infections and body mass index

Andrology, EarlyView.
Abstract Background The constitutive Leydig cell hormone insulin‐like peptide 3 (INSL3) is considered a good estimate of the adult Leydig cell functional capacity and appears to remain relatively consistent throughout adult male life, only gradually declining into old age.
Richard Ivell, Bilal Tulumcu, Waleed Alhujaili, Ravinder Anand‐Ivell   +3 more
wiley   +1 more source

Development of a nomogram for sperm retrieval at microTESE for idiopathic non‐obstructive azoospermia in a multi‐center cohort study

Andrology, EarlyView.
Abstract Background Non‐obstructive azoospermia (NOA) affects approximately 10% of infertile men and represents a major challenge in assisted reproductive technology (ART). A model that includes histological variants could be helpful in predicting sperm retrieval rate (SRR) after microdissection testicular sperm extraction (mTESE) in patients affected ...
Giorgio Ivan Russo, Edoardo Pozzi, Fausto Negri, Marco Falcone, Emanuele Zupo, Mirko Preto, Maria Giovanna Asmundo, Sandrine Chamayou, Murat Dursun, Ateş Kadıoğlu, Andrea Salonia   +10 more
wiley   +1 more source

Microbiology and immune mechanisms associated with male infertility

Frontiers in Immunology, 2023
Up to 50% of infertility is caused by the male side. Varicocele, orchitis, prostatitis, oligospermia, asthenospermia, and azoospermia are common causes of impaired male reproductive function and male infertility.
Jin Chen, Jinyu Chen, Yiwei Fang, Qiuzi Shen, Kai Zhao, Chunyan Liu, Huiping Zhang   +6 more
doaj   +1 more source

Testicular mass frozen section examination: Pathological insights and diagnostic accuracy

Histopathology, EarlyView.
Frozen section examination on testicular excisional biopsy is accurate and can help avoid unnecessary radical orchidectomy. A very high concordance rate between frozen section diagnosis and permanent diagnosis was obtained with no false negatives.
Roselyne Choiniere, Willem P A Boellaard, Marij Dinkelman‐Smit, Geert J L H van Leenders   +3 more
wiley   +1 more source