Results 51 to 60 of about 12,428 (228)

Fertility Concerns and Outcomes Among Adolescent and Young Adult Males With Melanoma Receiving Immunotherapy: A Mixed‐Methods Study

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Introduction Immune checkpoint inhibitors (ICIs) are often the initial treatment choice for melanoma, the third most common cancer in the adolescent and young adult (AYA) male population. Although ICIs have improved survival rates, their effects on male fertility and the adequacy of related counseling remain unclear.
Haadi Ali, Ellen Wold, Tarek Haykal, Peter Dawood, Victoria Wytiaz   +4 more
wiley   +1 more source

Dualistic Roles of High Mobility Group Box 1 in Cancer and Inflammation

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background The High Mobility Group Box 1 (HMGB1) protein, a member of the HMG family, plays a crucial role in both cancer progression and inflammatory responses. HMGB1 can act as a damage‐associated molecular pattern (DAMP) to activate immune responses and modulate inflammation.
Wen Zeng, Xu Zhang, Yulu Jiang, Yuxiang Luo, Zuao Wang, Xiaohong Du, Leifeng Chen   +6 more
wiley   +1 more source

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, Volume 1, Issue 3, Page 322-358, December 2025.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Clinical perspectives and comparisons between immunoglobulin G4‐related disease and antineutrophil cytoplasmic antibody‐associated vasculitis

Rheumatology &Autoimmunity, Volume 5, Issue 4, Page 267-274, December 2025.
Clinical perspectives and comparisons between immunoglobulin G4‐related disease and antineutrophil cytoplasmic antibody‐associated vasculitis. Abstract Both immunoglobulin G4‐related disease (IgG4‐RD) and antineutrophil cytoplasmic antibody (ANCA)‐associated vasculitis (AAV) are systemic disorders that affect a wide range of organs.
Wenhuan Zeng, Mingxin Bai, Yanying Liu
wiley   +1 more source

Acute Scrotal Pain and Swelling in Pediatric Emergency Medicine: A Narrative Review of Diagnostic and Management Challenges

The Journal of Pediatric Academy
Acute scrotal pain in children is a common but diagnostically complex emergency, with testicular torsion being the most time-critical differential diagnosis.
Ahmed Gamal Mohamed Abdelkhalk
doaj   +1 more source

Activation of the NLRP3 Inflammasome Pathway by Prokineticin 2 in Testicular Macrophages of Uropathogenic Escherichia coli- Induced Orchitis

Frontiers in Immunology, 2019
Infections of the reproductive tract are known to contribute to testicular inflammatory impairment, leading to an increase of pro-inflammatory cytokines such as IL-1β, and a decline in sperm quality.
Ying Li, Ying Li, Yufang Su, Ting Zhou, Zhiyong Hu, Jiajing Wei, Wei Wang, Chunyan Liu, Huiping Zhang, Kai Zhao   +9 more
doaj   +1 more source

Update and new advances in fertility preservation and cancer

CA: A Cancer Journal for Clinicians, Volume 75, Issue 6, Page 602-629, November/December 2025.
Abstract Adolescents and young adults with a cancer diagnosis face unique challenges during treatment and into survivorship related to fertility and family building. This review provides an updated overview of the impact of cancer and its associated treatments, including novel treatments in male and female fertility.
Gwendolyn P. Quinn, Michelle Bayefsky, Brooke Cherven, Lauren V. Ghazal, Kara N. Goldman, Nina Francis Levin, Leena Nahata, Bobby Najari, Sameer Thakker, Daniel R. Greenberg, Joshua A. Halpern, Susan T. Vadaparampil   +11 more
wiley   +1 more source

First Reports of Canine Coccidioidomycosis in the Paso del Norte Region, Mexico–USA: A 10‐Case Series

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
ABSTRACT Objectives Present a series of cases of dogs with coccidioidomycosis residing in Juarez, city in northwest Mexico and part of the binational Mexico–USA metropolitan area ‘Paso del Norte’ which connects with El Paso, TX, and Donna Ana, NM, highlighting the variations observed in the clinical manifestations.
Carlos A Rodríguez‐Alarcón, Ramón Wong‐Saavedra, Javier A Garza‐Hernández, Diana B Rios‐Arias, Edgar A Lomelí, Erick DJ De Luna‐Santillana, Ramón Rivera‐Barreno, Alvaro Medina‐Melchor, Abihail Pérez‐Mireles, Marianna I Quintana‐García, Jaime R Adame‐Gallegos   +10 more
wiley   +1 more source

A Systematic Review and Meta‐Analysis on the Prevalence of Brucella melitensis in Sheep and Goat

Veterinary Medicine and Science, Volume 11, Issue 6, November 2025.
GRAPHICAL ABSTRACT: Brucellosis, caused by Brucella melitensis, is a major neglected zoonotic disease transmitted from sheep and goats to humans. This systematic review and meta‐analysis of studies published between 2010 and 2023 revealed a pooled global prevalence of 2.46% in goats, 8.07% in sheep, and 5.54% combined, with substantial regional ...
Seemanta Das, Pronab Das, Ankon Das, F. M. Yasir Hasib, Sharmin Chowdhury   +4 more
wiley   +1 more source

Clinical insights: Brucellosis-induced febrile orchitis - A case report and treatment strategy

Urology Case Reports
Brucellosis, a systemic infection, can affect various organs, including the genitourinary system, causing epididymo-orchitis in 2%–20 % of cases. This report details a 34-year-old Thai male migrant worker with febrile orchitis.
Dor Golomb, Ido Bar, Tal Brosh-Nissimov, Daniel Leshin-Carmel, Amir Cooper, Orit Raz   +5 more
doaj   +1 more source