Results 111 to 120 of about 11,847,542 (311)

The order of thought and the order of words

open access: yesKalbotyra, 2007
Šiame straipsnyje pateikiama vertimo analizė, atsižvelgiant į kalbų struktūrinius skirtingumus ir galimybes, kurias suteikia funkcinės sakinio perspektyvos (FSP) realizavimas. Pateikiami lietuvių grožinės literatūros tekstai ir jų angliškieji vertimai, siekiant nustatyti, kokią rolę funkcinės sakinio perspektyvos perteikime vaidina žodžių tvarka ...
openaire   +4 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

PROSPECTS FOR THE USE OF CONTRACEPTIVE VAGINAL PATCH ZB-06

open access: yesSiberian Journal of Life Sciences and Agriculture
With the high frequency of unplanned pregnancies in many countries, there is an urgent need for more affordable and effective contraceptives. In recent years, scientists around the world have been actively developing new methods of barrier contraception.
Yuri A. Kucherenko   +4 more
doaj   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Constitution and by-laws / Military Order of the Loyal Legion of the United States.

open access: yes, 1877
47 p.
Military Order of the Loyal Legion of the United States.
core  

Stem cells in the treatment of diabetes caused by surgical treatment of pancreatic cancer

open access: yesКлинический разбор в общей медицине
Surgical treatment of pancreatic cancer often leads to the development of diabetes mellitus (DM) due to the loss of a significant mass of functioning pancreatic tissue. Currently, the possibility of using stem cells (SC) to restore the islet apparatus of
Vitaly B. Kaliberdenko   +6 more
doaj   +1 more source

On ordered graphs and graph orderings

open access: yesDiscrete Applied Mathematics, 1994
The main result of this paper is: For every oriented graph \(\vec G\) with in-degree for every vertex at least 2 there is no graph \(H\) such that every strong orientation \(\vec H\) of \(H\) contains a copy of \(\vec G\). This disproves a conjecture of \textit{M. Cochand} and \textit{P. Duchet} [Algorithms Comb. 8, 39-46 (1989; Zbl 0698.05055)].
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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