Reconstructing enzyme evolution by protein engineering
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The effect of macroeconomic variables on exchange rate: Evidence from Ghana
The study examined the effect of macroeconomic variables on exchange rate in Ghana using a multivariate modeling technique of the Vector Autoregression (VAR) and focusing on impact of broad money supply (M2), lending rate, inflation and real GDP on ...
Samuel Antwi +3 more
doaj +1 more source
Incommensurate Spiral Order from Double-Exchange Interactions [PDF]
The double exchange model describing interactions of itinerant electrons with localized spins is usually used to explain ferromagnetism in metals. We show that for a variety of crystal lattices of different dimensionalities and for a wide range of model parameters the ferromagnetic state is unstable against a non-collinear spiral magnetic order.
Azhar, Maria, Mostovoy, Maxim
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
The examination of signaling theory versus pecking order theory: Evidence from Tehran Stock Exchange [PDF]
This study investigates the explanatory power of leverage and cash flows in future cash flow prediction in Tehran Stock Exchange by considering Signaling Theory and Pecking Order Theory. Based on theoretical foundations, the regression models of leverage
Elahe Mahdavi Sabet, Mohammad Hassani
doaj
Macrospin dynamics in antiferromagnets triggered by sub-20 femtosecond injection of nanomagnons
Magnetic order in nature is defined by the exchange interaction, however its understanding on the ultrafast- and nanometer-scales is limited. Here, the authors follow the femtosecond sub-nanometer dynamics of the antiferromagnetic order parameter in ...
D. Bossini +7 more
doaj +1 more source
Higher-order co-moments in asset pricing on the stock exchange in Brazil
This study seeks to identify the behavior of systemic asymmetry (coskewness) and systemic kurtosis (cokurtosis) in asset pricing on the Brazilian stock exchange (in BM&F Bovespa).
Paulo Vitor Jordão da Gama Silva +2 more
doaj +1 more source
Sacramental Exchange: Eschatological Economy and Consumption Ritual
Contemporary sacramental theology construes the sacraments as a symbolic gift exchange between God and humanity; God initiates in the ministry of Jesus Christ, and human beings acknowledge and respond to God’s gift.
Kimberly Belcher
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source

