Results 131 to 140 of about 794,303 (218)

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

Advanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang, Xuedong Wang, Mengyao Wang, Qian Zhou, Lusheng Wang, Shuai Cheng Li   +5 more
wiley   +1 more source

Generalization bounds for a generator-regularized InfoGAN-inspired adversarial objective. [PDF]

Front Artif Intell
Hasan M, Muia MN, Islam MM.
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Efficient EM Estimation for the Pogit Model via Polya-Gamma Augmentation. [PDF]

Entropy (Basel)
Gutiérrez I, Ramírez S, Jofré L.
europepmc   +1 more source

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source

Lattice Genome Framework for Regionally Tailored Component‐Level Multi‐Objective Design in Additive Manufacturing

Advanced Science, EarlyView.
A Lattice Genome framework links geometric and process “genes” to lattice “phenotypes” via correction‐calibrated high‐throughput simulations and a growing performance database. Genome‐driven retrieval and recombination of unit cells enables component‐level, regionally tailored multi‐objective design: stress fields are programmed under constant relative
Haoyuan Deng, Yufan Zhao, Mingyang Cao, Haiou Yang, Pan Wang, Hongze Wang, Hao Wang, Akihiko Chiba, Xin Lin   +8 more
wiley   +1 more source

An adaptive hybrid quadrature scheme: Combining Simpson's rule and Gaussian quadrature for enhanced numerical integration. [PDF]

PLoS One
Asgedom AA, Kefela YY.
europepmc   +1 more source

Optimal Grazing Exclusion Duration to Enhance Soil Carbon Sequestration in Degraded Grasslands

Advanced Science, EarlyView.
Across China, grazing exclusion reaches the national mean soil organic carbon recovery benchmark sooner in high‐MAP regions (> 500 mm), but recovery is much slower where MAP < 300 mm. Scaling this strategy to 70% of China's degraded grasslands would sequester about 1.52 Pg of soil carbon over 10 years—roughly 17% of annual global fossil‐fuel emissions.
Bin Zhang, Chongzhi Sun, Dongmei Xue, Paul Christiaan Struik, Tongrui Zhang, Jiayue Liu, Tingting Xing, Ziyang Liu, Shiming Tang, Ke Jin   +9 more
wiley   +1 more source

Inference on function-valued parameters using a restricted score test. [PDF]

J R Stat Soc Series B Stat Methodol
Hudson A, Carone M, Shojaie A.
europepmc   +1 more source