Results 21 to 30 of about 2,176 (251)

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Extended resolution simulates binary decision diagrams [PDF]

open access: yes, 2007
We prove that binary decision diagrams [R. Bryant, Symbolic Boolean manipulation with ordered binary decision diagrams, ACM Comput. Surveys 23 (3) (1992)] can be polynomially simulated by the extended resolution rule of [G.S.
Nicolas Peltier, Peltier, Nicolas
core   +1 more source

Ordered Functional Decision Diagrams: A Functional Semantics For Binary Decision Diagrams

open access: yes, 2020
We introduce a novel framework, termed $λ$DD, that revisits Binary Decision Diagrams from a purely functional point of view. The framework allows to classify the already existing variants, including the most recent ones like Chain-DD and ESRBDD, as implementations of a special class of ordered models.
Thibault, Joan, Ghorbal, Khalil
openaire   +2 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Comparing BDD and SAT based techniques for model checking Chaum's Dining Cryptographers Protocol [PDF]

open access: yes, 2006
We analyse different versions of the Dining Cryptographers protocol by means of automatic verification via model checking. Specifically we model the protocol in terms of a network of communicating automata and verify that the protocol meets the anonymity
Raimondi, F.   +5 more
core  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

open access: yesFEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss   +7 more
wiley   +1 more source

Zero-Suppressed Binary Decision Diagrams Resilient to Index Faults [PDF]

open access: yes, 2014
This paper discusses the error resilience of Zero-Suppressed Binary Decision Diagrams (ZDDs), which are a particular family of Ordered Binary Decision Diagrams used for representing and manipulating combination sets.
V. Ciriani   +6 more
core   +1 more source

White Matter Hyperintensity Burden and Short‐Interval Change Associated With Sleep Apnoea in the UK Biobank

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Purpose White matter hyperintensities (WMH) are a core neuroimaging marker of cerebral small vessel disease (CSVD). Sleep apnoea (SA) is a recognized vascular risk factor, but its associations with regional WMH burden, short‐interval WMH change and cognitive performance in population‐based cohorts remain incompletely defined. We
Peng Cheng   +4 more
wiley   +1 more source

Complexity of XOR/XNOR boolean functions: a model using binary decision diagrams and back propagation neural networks

open access: yesJournal of Computer Science and Technology, 2007
This paper proposes a model that predicts the complexity of Boolean functions with only XOR/XNOR min-terms using back propagation neural networks (BPNNs) applied to Binary Decision Diagrams (BDDs). The BPNN model (BPNNM) is developed through the training
Ali Assi   +3 more
doaj  

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