Results 81 to 90 of about 483,652 (264)
Theoretical and methodological foundations of research on the design of physical fitness and recreational technologies [PDF]
Физическое воспитание и студенческий спортHealth preservation and health promotion are among the most popular research topics in the modern world. Unfortunately, young people do not pay due attention to this issue, do not apply modern methods and ways to increase the body’s resistance to ...
Pestrikov, Evgenii A.
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On the order of a group of even order
Journal of Algebra, 2007 Let \(G\) be a group of even order with a unique conjugacy class of involutions. In the paper under review the authors provide an upper bound for the order of \(G\) in terms of the centralizer \(H=C_G(t)\) of an involution \(t\) in \(G\). As an application the authors provide examples of sporadic simple groups, the groups \(Ly\) and \(Th\), whose ...
Harada, Koichiro, Miyamoto, Masahiko
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
ReligionsThis essay examines Jean-Luc Marion’s phenomenal model of the Trinity expounded in his recent book D’Ailleurs, la révélation (2020) and attempts to give an initial assessment from a theological perspective. Since Marion’s programme is largely indebted to
Beáta Tóth
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The Bulletin of the Royal College of Surgeons of EnglandEmbracing the College values.
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source