Results 151 to 160 of about 474,403 (297)

Data, not documents: Moving beyond theories of information‐seeking behavior to advance data discovery

Journal of the Association for Information Science and Technology, Volume 76, Issue 4, Page 649-664, April 2025.
Abstract Many theories of human information behavior (HIB) assume that information objects are in text document format. This paper argues four important HIB theories are insufficient for describing users' search strategies for data because of assumptions about the attributes of objects that users seek.
Anthony J. Million, Jeremy York, Sara Lafia, Libby Hemphill   +3 more
wiley   +1 more source

Multiple imputation for missing values in ordinal variables from cancer registry data when performing Cox proportional hazards regression. [PDF]

BMC Med Res Methodol
Kästner A, Hoffmann W, Hüsing J, Stang A, Hüsing A.   +4 more
europepmc   +1 more source

Model‐informed drug development to support nemolizumab clinical development in adults and adolescents with moderate to severe atopic dermatitis

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Population pharmacokinetic (popPK) and pharmacokinetic‐pharmacodynamic (PK/PD) models were developed to support clinical development of nemolizumab, a humanized monoclonal antibody targeting the IL‐31 receptor α, in adolescents and adults with moderate‐to‐severe atopic dermatitis (AD).
Floris Fauchet, Anna Largajolli, Petra M. Jauslin, Emilie Schindler, Mourad Hamimed, Wannee Kantasiripitak, Antonio Gonçalves, Eline Van Maanen, Khaled Benkali, Tomohisa Saito, Jonathan I. Silverberg, Andreas Wollenberg, Michael Graeber, Liliana Ulianov, Christophe Piketty, Luca Loprete, Vincent Duval, Nathalie Wagner   +17 more
wiley   +1 more source

Intravenous lanadelumab for the treatment of moderately ill COVID‐19 patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Kallikrein‐kinin system (KKS) dysregulation is hypothesized to play a pathogenetic role in COVID‐19‐associated pulmonary oedema. To investigate the efficacy and safety of intravenous lanadelumab, a monoclonal antibody that inhibits plasma kallikrein, in COVID‐19, we conducted a phase 2, open‐label, randomized‐controlled, proof‐of‐concept ...
Job J. Engel, Christine van Linge, W. Joost Wiersinga, Ilse J. E. Kouijzer, Quirijn de Mast, Robert‐Jan Hassing, Danique J. H. Huijbens, Helen L. Leavis, Roger Schutgens, Coen Maas, Kit C. B. Roes, Frank L. van de Veerdonk, Roger Brüggemann   +12 more
wiley   +1 more source

Community pharmacists' practices and perspectives on deprescribing high‐risk psychotropic medicines: National survey findings

British Journal of Clinical Pharmacology, EarlyView.
Aim To explore the practices, confidence and perspectives of community pharmacists in deprescribing high‐risk psychotropic medicines, including opioid analgesics, benzodiazepine, gabapentinoids and medicinal cannabis. Methods An anonymous, cross‐sectional national online survey was conducted between January and April 2025 among Australian community ...
Monica Jung, Louisa Picco, Aili V. Langford, Rose Laing, Jana Dostal, Suzanne Nielsen   +5 more
wiley   +1 more source

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

A Measurement Model to Quantify Systemic Bacilli Load in Severe HIV-Associated Tuberculosis. [PDF]

Open Forum Infect Dis
Sossen B, Schutz C, Boloko L, Broger T, Ward A, Bekiswa A, Balfour A, Shey M, Meintjes G, Barr DA.   +9 more
europepmc   +1 more source

Contrasting roles of school and public libraries in lower primary pupils' reading

British Educational Research Journal, EarlyView.
Abstract Libraries represent an important institutional component of children's reading socialisation, yet their role is often treated as uniform despite substantial differences between school and public libraries. This study examines how visits to school and public libraries relate to pupils' reading attitudes, practices and self‐assessed reading ...
Kateřina Balcarová, Jiří Balcar
wiley   +1 more source

The Burden of Laryngeal Cleft in Children With Refractory Asthma: A 10-Year Multicenter Experience. [PDF]

Pediatr Pulmonol
Nazario AN, Rebaza A, Craver E, Pinillos PM.   +3 more
europepmc   +1 more source

Validation of the ABL + DT model: An ecosystemic framework for integrating arts and digital technologies in primary education

British Educational Research Journal, EarlyView.
Abstract Primary education teachers face increasing challenges in engaging diverse learners and fostering creativity, digital competence and other transversal skills, often lacking clear, practical guidance for integrating these skills into their classrooms.
Nella Escala, Montse Guitert, Teresa Romeu   +2 more
wiley   +1 more source