ABSTRACT Aims Petrelintide is a long‐acting amylin analogue in development for weight management. The safety, tolerability, pharmacokinetics, and pharmacodynamics of petrelintide were evaluated in single ascending dose (SAD) and multiple ascending dose (MAD) trials. Materials and Methods Both trials were randomized, placebo‐controlled, and double‐blind.
Minna Brændholt Olsen +6 more
wiley +1 more source
Integrated Optomechanical Analysis of the Impact of an Ø 800 mm Primary Mirror on the Imaging Quality of an Optical System. [PDF]
Liu R, Zhang Y, Liu Y, Li Q.
europepmc +1 more source
Felons’ chattels and English living standards in the later fourteenth and fifteenth centuries
Abstract The later fourteenth and fifteenth centuries have long occupied an intriguing and contested place in discussions of England's long‐run economic development. One key issue around which debate has coalesced is the living standards of the population as a whole and of different groups within it. We contribute to this debate by bringing forward new
Chris Briggs +4 more
wiley +1 more source
A Candidatus liberibacter Asiaticus effector, CLIBASIA_00185 controls sugar metabolism, phenylpropanoid biosynthesis, and endocytosis pathway in Citrus sinensis. [PDF]
Zhang S, Lu Y, He J, Zhou C, Wang X.
europepmc +1 more source
Golden weapons and golden fetters: From the gold standard to the new geopolitics
Abstract This paper explores the historical relationship between monetary regimes, security concerns, and geopolitical tensions, particularly focusing on the role of gold. Throughout history, monetary systems have been deeply intertwined with international state systems and security provisions.
Harold James
wiley +1 more source
Civilly Disobeying What? On Directness and Relevance in Civil Disobedience
Abstract Recent acts of civil disobedience in protest against politicians' inaction about climate change have often targeted works of art to provoke public opinion on the issue. Such initiatives have attracted criticism from those who object to this form of political dissent.
Federico Zuolo
wiley +1 more source
A streamlined integrated system integrating lysate release, freeze-dried reagents for multiplex polymerase chain reaction, and intelligent analysis for TORCHes pathogen identification. [PDF]
Fu M +12 more
europepmc +1 more source
From products to smart solutions: A value‐creation approach
Abstract Smart solutions comprise a synergy of products, services, software, connectivity, data, and intelligence. This study examines the evolution of a manufacturer into a smart solution provider, highlighting the role of value‐creation capabilities, activities, and practices. Through a longitudinal, in‐depth single‐case study of a leading technology
Tayyab Warraich +4 more
wiley +1 more source
Analysis of the main components of LSPN based on broadly targeted metabolomics technology. [PDF]
Qin F, Chen Y, Wang D, Li J, Zhu S.
europepmc +1 more source
Ordinal proof theory of Kripke-Platek set theory augmented by strong reflection principles
Diese Arbeit umfasst vier Teile. Im ersten Teil wird eine Ordinalzahlanalyse der Kripke-Platek Mengenlehre, erweitert um ein Reflexionsschema für erststufige Formeln, erarbeitet. Im zweiten Teil wird diese Ordinalzahlanalyse genutzt, um mit Hilfe subrekursiver Hierarchien eine Charakterisierung der beweisbar rekursiven Funktionen der im ersten Teil ...
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