Results 141 to 150 of about 311,267 (287)

Repeated Intake of Grapefruit Juice Inhibits CYP2B6, CYP2C9, CYP2C19, and CYP3A4 while Lingonberry Powder Does Not Induce Major CYP Enzymes in Humans

Clinical Pharmacology &Therapeutics, EarlyView.
Grapefruit juice is a well‐established inhibitor of cytochrome P450 (CYP) 3A4, but its effects on other CYP enzymes or organic anion transporting polypeptides (OATPs) are not fully characterized in humans. Recently, lingonberry powder was shown to induce murine CYP enzymes. We investigated the effects of lingonberry powder and grapefruit juice on seven
Laura Aurinsalo, Outi Lapatto‐Reiniluoto, Mika Kurkela, Mikko Neuvonen, Eeva Moilanen, Mikko Niemi, Aleksi Tornio, Janne T. Backman   +7 more
wiley   +1 more source

Applicability of XRF technique to Rb-Sr chemical dating of K-bearing minerals

Мінеральні ресурси України, 2014
The possibility of Rb-Sr chemical dating for K-bearing micas by XRF method has been considered by analogy with a CHIME (CHemical Isochronal MEthod) for monazites.
O. A. Andreiev
doaj  

Strain‐based modeling and analysis for rock blasting and geomechanics applications

Deep Underground Science and Engineering, EarlyView.
This paper introduces a novel strain‐based modeling approach for blasting and geomechanical applications, using measurable variables like particle velocity, strain, and displacement. By bypassing complex constitutive relations, strain‐based models capture critical blasting trends and full‐blast design parameters with minimal calibration.
Ruilin Yang
wiley   +1 more source

Quantification of rheological parameters in deep‐sea mining plumes

Deep Underground Science and Engineering, EarlyView.
This study explores the variations in rheological properties observed during the propagation of deep‐sea mining plumes, utilizing rheological test data obtained from kaolin clay plumes. Subsequently, taking into account the differences in sediment properties, the effects of clay content and clay mineral composition on the rheological parameters of ...
Xiaolei Liu, Yihan Liu, Yonggang Jia, Xingsen Guo   +3 more
wiley   +1 more source

Optimization of cut‐hole layout under high in situ stress based on numerical simulation and field tests

Deep Underground Science and Engineering, EarlyView.
This study investigates the blast‐induced rock damage patterns under different cut‐hole layouts and ground stress conditions through numerical simulations and field tests. The findings in this study provide valuable insights for similar underground engineering applications.
Junjie Zhao, Diyuan Li, P. G. Ranjith, Xinxin Lü, Yanliang Li, Xiaoli Su   +5 more
wiley   +1 more source

Geological and geotechnical challenges on the Great Dyke of Zimbabwe and their impact on hardrock pillar design

Deep Underground Science and Engineering, EarlyView.
The Great Dyke of Zimbabwe is notable for its rich platinum group metal deposits but poses significant geological and geotechnical challenges due to its complex rock types and structural features. Traditional pillar design methods are insufficient for addressing these complexities; the study suggests incorporating advanced techniques such as machine ...
Tawanda Zvarivadza, Hendrik Grobler, Moshood Onifade, Manoj Khandelwal   +3 more
wiley   +1 more source

Exploring the role of apolipoprotein ε4 in progressive myoclonic epilepsy type 1

Epileptic Disorders, EarlyView.
Abstract Objective Progressive myoclonic epilepsy type 1 (EPM1) is a neurodegenerative disease caused by biallelic variants in the cystatin B (CSTB) gene. Despite a progressive course, phenotype severity varies among patients, even within families. We studied the potential role of APOE ε4 in modifying phenotypic diversity in EPM1, given its established
Janina Gunnar, Yawu Liu, Henri Eronen, Tarja Joensuu, Marja Äikiä, Jelena Hyppönen, Katri Silvennoinen, Esa Mervaala, Juhana Hakumäki, Anna‐Elina Lehesjoki, Reetta Kälviäinen   +10 more
wiley   +1 more source

Mechanisms of SCN2A loss of function do not predict presence or phenotype of epilepsy

Epilepsia, EarlyView.
Abstract Objective SCN2A loss‐of‐function (LoF) variants are associated with epilepsy (onset age ≥ 3 months), intellectual disability (ID), and autism spectrum disorder (ASD). Despite numerous identified variants and the description of phenotypic subgroups, relationships between Nav1.2 channel dysfunction and clinical phenotypes remain unclear.
Marsha Tan, Beatrice Southby Goad, Meagan Allen, Jill Rodda, Kay L. Richards, Simone L. Ardern‐Holmes, Daniel Bamborschke, Daniel Fritzen, Inna Hughes, Kate Riney, Ana Roche Martinez, Angelo Russo, Adriane Sinclair, Stefano Sartori, Marina Trivisano, Angela De Dominicis, Nicola Specchio, Rikke S. Møller, Ingrid E. Scheffer, Walid Fazeli, Markus Wolff, Steven Petrou, Katherine B. Howell, Géza Berecki   +23 more
wiley   +1 more source

A Comprehensive Review on the Significance, Sources, and Applications of Virtual Water on Global Platform

Food Safety and Health, EarlyView.
A conceptual framework of virtual water showing its sources, major applications, components of the virtual water footprint, and emerging future directions. The diagram emphasizes the growing role of virtual water in global sustainability and resource planning.
Priti Bhowmik, Charu Rajpal, Vinay Kumar Pandey   +2 more
wiley   +1 more source

Origins of the Pangkaimen Au Deposit in the Northern Great Xing'an Range, China: Evidence From Geochronological, Geochemical, Fluid Inclusion, and H–O–S–Pb Isotope Data

Geological Journal, EarlyView.
The Pangkaimen Au–Ag deposits belong to the epithermal Au deposits, which are of great significance for guiding the research and development of this type of gold deposit. Metallogenic model diagram of Pangkaimen Au–Ag deposit. ABSTRACT The gold (Au) metallogenic belt in the northern Great Xing'an Range is characterised by the wide occurrence of the ...
Sheng Lu, Hongpeng Chen, Chenglu Li, Ye Wang, Tiesheng Li, Rigen Wu, Zengtao Li, Zhichao Song, Xiannan Zhu   +8 more
wiley   +1 more source