Results 231 to 240 of about 522,520 (309)

Genotype and injury severity modulate the effects of traumatic brain injury on sleep in <i>Drosophila</i>. [PDF]

MicroPubl Biol
Pisano L, Shahandeh MP.
europepmc   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Interrogating cognitive and neural group variation in childhood: Examples in adolescent brain cognitive development and Oregon attention-deficit/hyperactivity disorder-1000 cohorts. [PDF]

J Psychopathol Clin Sci
Karalunas SL, Atluri G, Tamm L, Dudley J, Maloney T, Pieper S, Jones SA, Simon J, Duong PA, Nagel BJ, Epstein JN.   +10 more
europepmc   +1 more source

Uncovering Coenzyme Q10‐Related Genetic Determinants of Statin‐Associated Muscle Symptoms: Evidence from the UK Biobank and the All of Us Research Program

Clinical Pharmacology &Therapeutics, EarlyView.
Statin‐associated muscle symptoms (SAMS) are frequent adverse effects of statin therapy and have been hypothesized to result from impaired coenzyme Q10 (CoQ10) biosynthesis. Although genetic determinants of CoQ10 levels have been reported, genome‐wide association studies (GWASs) conducted specifically in statin users are lacking. Moreover, direct CoQ10
Da Hoon Lee, Yoon‐A Park, Yubin Song, Ji‐Min Han, Kyung Hee Choi, Myeong Gyu Kim, Hye Sun Gwak   +6 more
wiley   +1 more source

Imaging the impact of rotifer consumption on bacterial behaviors in the zebrafish gut. [PDF]

PLoS One
Marquez Rosales S, Amitabh P, Olmstead EM, Avey EPR, Wall ES, Ortiz de Ora L, Wiles TJ, Parthasarathy R.   +7 more
europepmc   +1 more source

Resolving CYP2D6 Structural Complexity with Long‐Read Sequencing: Implications for Tamoxifen Precision Dosing in Thai Breast Cancer Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Cytochrome P450 2D6 (CYP2D6)‐mediated bioactivation of tamoxifen to endoxifen is a key determinant of therapeutic efficacy in estrogen receptor‐positive breast cancer. In Asian populations, the high prevalence of structurally complex CYP2D6 alleles complicates conventional genotyping, limiting accurate genotype–phenotype correlation.
Usa Boonyuen, Sirinyatorn Talukam, Beatriz Aira C. Jacob, Wayu Matphong, Kamonwan Chamchoy, Onrapak Reamtong, Nuntana Meesiripan, Junya Yamagishi, Matthew Phanchana, Chayanoot Rattadilok   +9 more
wiley   +1 more source

Dual versus single implant fixation for geriatric distal femur fractures: protocol for a randomised, controlled pilot study at five US level 1 trauma centres. [PDF]

BMJ Open
Haller J, Achebe CC, Oman G, Konda S, Garner M, Yuan B, Marchand LS, DeKeyser GJ.   +7 more
europepmc   +1 more source

Impact of Operator Specialization and on‐Site Evaluation on Nondiagnostic Thyroid Fine‐Needle Aspiration: A Comparative Study

Diagnostic Cytopathology, EarlyView.
ABSTRACT Background Thyroid fine‐needle aspiration (FNA) is the primary diagnostic method for evaluating thyroid nodules; however, nondiagnostic results remain a significant limitation, often leading to repeat procedures and delayed diagnosis. Operator specialization and rapid on‐site evaluation (ROSE) have been proposed as strategies to improve ...
Fatlinda Sadiku, Marija Škerlj, Vesna Ramljak   +2 more
wiley   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Liquid Biopsy Differentiation of Pancreatic Cancer From Non-Cancerous Pancreatic Disease Using Dielectrophoresis-Recovered Nanoparticles Carrying Cell-Free DNA and Protein Biomarkers. [PDF]

Small
Malakian A, Modestino A, Bueno J, Machireddy A, Ware J, Hamilton S, Stimson E, Mitchell S, Saldivar JC, Woodfin AR, Dambacher CM, Gustafson K, Shea D, Ranganathan S, Sasanpour M, Ross C, Keith D, Lim JY, Song X, Lippman SM, Sears R, Morgan T, Heller M, Ibsen SD.   +23 more
europepmc   +1 more source