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Heparin binding activity of orf virus F1L protein
Virus Research, 2004The orf virus is the type species of the Parapoxvirus genus and is the causative agent of contagious echtyma, a debilitating skin disease of sheep and goats, which can also affect man. The virus exhibits a restricted host range, even if it has been shown to bind to a wide range of tissues of non-permissive species.
SCAGLIARINI, ALESSANDRA +5 more
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Orf virus circulation in cattle in Turkey
Comparative Immunology, Microbiology and Infectious Diseases, 2019Orf virus (ORFV) causes contagious skin disease that mainly affects sheep and goats with zoonotic potential. However, there is not enough information about the association between ORFV and occurrence of skin disease in cattle. The present study describes outbreaks of ORFV infection in cattle in different provinces that are located in the Aegean ...
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Cytokines and their inhibitors in orf virus infection
Veterinary Immunology and Immunopathology, 1996The epitheliotropic parapoxvirus, orf virus, can repeatedly infect sheep skin. A specific immune response is generated as reinfections induce smaller lesions with quicker resolution times than primary lesions. Cyclosporin-A treatment abrogates this partial immunity.
D, Haig +10 more
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Orf virus infection in pregnancy.
South Dakota journal of medicine, 1994Orf virus infection is endemic among sheep and goats, and can occur in humans who handle these animals. Orf virus infection in humans causes a characteristic skin lesion, and systemic symptoms can occur. Very little is known about Orf virus infection in human pregnancy.
W J, Watson, M W, Meyer, D L, Madison
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Cytotoxic Antibodies in Orf Virus Infection of Sheep
Zentralblatt für Veterinärmedizin Reihe B, 2010Summary Serum samples from sheep experimentally or naturally infected with orf virus were tested for cytotoxic antibody by a 51Cr release test. Cytotoxic antibodies developed within one month of experimental infection, persisted for 2—4 weeks and did not rise significantly in titre after a first or second re-exposure to virus 9 or 16 weeks later ...
G, Koptopoulos, H W, Reid, I, Pow
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The immune and inflammatory response to orf virus
Comparative Immunology, Microbiology and Infectious Diseases, 1997Orf virus is a zoonotic, epitheliotropic DNA parapox virus that principally infects sheep and goats. The fact that the virus can repeatedly reinfect sheep has provoked an interest in the underlying cellular, virological and molecular mechanisms for its apparent escape from the host protective immune response.
D M, Haig +4 more
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Immune responses of patients to orf virus infection
British Journal of Dermatology, 1994Orf is a disease of sheep and goats which is caused by a parapox virus. It can be transmitted to humans, and is considered an occupational hazard by those handling sheep. In this paper we present the first report of both cell-mediated and humoral immune responses to naturally acquired orf virus infection in humans.
D L, Yirrell, J P, Vestey, M, Norval
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Molecular characterization of Brazilian isolates of orf virus
Veterinary Microbiology, 2000Outbreaks of an epidermic disease suggesting parapox virus infections have been observed in all major herds of sheep and goats from different geographical areas of Brazil. Clinical samples (dried scabs) were collected and orf virus was isolated and characterized by electron microscopy in previous work.
C, Mazur +3 more
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Generation and Selection of Orf Virus (ORFV) Recombinants
2016Orf virus (ORFV) is an epitheliotropic poxvirus, which belongs to the genus Parapoxvirus. Among them the highly attenuated, apathogenic strain D1701-V is regarded as a promising candidate for novel virus vector vaccines. Our recent work demonstrated that those ORFV-based recombinants were able to induce protective, long-lasting immunity in various ...
Hanns-Joachim, Rziha +2 more
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