Results 211 to 220 of about 56,595 (259)
Comparison of cytokine responses to group B <i>Streptococcus</i> infection in a human maternal-fetal interface organ-on-a-chip system and <i>ex vivo</i> culture model of human gestational membranes. [PDF]
Infect ImmunKirk LA +10 more
europepmc +1 more source
Advances in the Model Structure of In Vitro Vascularized Organ-on-a-Chip. [PDF]
Cyborg Bionic SystYin H +7 more
europepmc +1 more source
The Evolution of In Vitro Toxicity Assessment Methods for Oral Cavity Tissues-From 2D Cell Cultures to Organ-on-a-Chip. [PDF]
ToxicsJităreanu A +6 more
europepmc +1 more source
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2020
Limitations of the current tools used in the drug development process, cell cultures, and animal models have highlighted the need for a new powerful tool that can emulate the human physiology in vitro. Advances in the field of microfluidics have made the realization of this tool closer than ever.
Ilka, Maschmeyer, Sofia, Kakava
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Limitations of the current tools used in the drug development process, cell cultures, and animal models have highlighted the need for a new powerful tool that can emulate the human physiology in vitro. Advances in the field of microfluidics have made the realization of this tool closer than ever.
Ilka, Maschmeyer, Sofia, Kakava
openaire +3 more sources
2020
Organs-on-chips, also known as "tissue chips" or microphysiological systems (MPS), are bioengineered microsystems capable of recreating aspects of human organ physiology and function and are in vitro tools with multiple applications in drug discovery and development. The ability to recapitulate human and animal tissues in physiologically relevant three-
Lucie A, Low +5 more
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Organs-on-chips, also known as "tissue chips" or microphysiological systems (MPS), are bioengineered microsystems capable of recreating aspects of human organ physiology and function and are in vitro tools with multiple applications in drug discovery and development. The ability to recapitulate human and animal tissues in physiologically relevant three-
Lucie A, Low +5 more
openaire +2 more sources
Scientific American, 2011
The article discusses the development of a microchip that simulates the activities and mechanics of entire organs and organ systems, called "organs on a chip." According to the author, organs on a chip would help scientists deal with some of the more challenging aspects of research, such as the need to experiment on whole animals.
openaire +2 more sources
The article discusses the development of a microchip that simulates the activities and mechanics of entire organs and organ systems, called "organs on a chip." According to the author, organs on a chip would help scientists deal with some of the more challenging aspects of research, such as the need to experiment on whole animals.
openaire +2 more sources
Engineered Biomimetic Membranes for Organ-on-a-Chip
ACS Biomaterials Science & Engineering, 2022Organ-on-a-chip (OOC) systems are engineered nanobiosystems to mimic the physiochemical environment of a specific organ in the body. Among various components of OOC systems, biomimetic membranes have been regarded as one of the most important key components to develop controllable biomimetic bioanalysis systems.
Maedeh Rahimnejad +12 more
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2021
Abstract Abstract: This chapter explores organs-on-a-chip, miniaturized bioprinted organ tissues enclosed in a microfluidic housing (microfluidics refers to very small-scale plumbing) that can mimic functions of human physiology or disease and are particularly effective when multiple tissue types—for example, lung, heart, and liver—can ...
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Abstract Abstract: This chapter explores organs-on-a-chip, miniaturized bioprinted organ tissues enclosed in a microfluidic housing (microfluidics refers to very small-scale plumbing) that can mimic functions of human physiology or disease and are particularly effective when multiple tissue types—for example, lung, heart, and liver—can ...
openaire +1 more source
Organ-on-a-chip systems for vascular biology
Journal of Molecular and Cellular Cardiology, 2021Organ-on-a-chip (OOC) platforms involve the miniaturization of cell culture systems and enable a variety of novel experimental approaches. These range from modeling the independent effects of biophysical forces on cells to screening novel drugs in multi-organ microphysiological systems, all within microscale devices.
Christian J, Mandrycky +4 more
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Organs-on-a-chip models for biological research
Cell, 2021We explore the utility of bioengineered human tissues-individually or connected into physiological units-for biological research. While much smaller and simpler than their native counterparts, these tissues are complex enough to approximate distinct tissue phenotypes: molecular, structural, and functional. Unlike organoids, which form spontaneously and
Gordana, Vunjak-Novakovic +2 more
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