Results 291 to 300 of about 61,131 (327)

Organs-on-a-Chip

2021
Abstract Abstract: This chapter explores organs-on-a-chip, miniaturized bioprinted organ tissues enclosed in a microfluidic housing (microfluidics refers to very small-scale plumbing) that can mimic functions of human physiology or disease and are particularly effective when multiple tissue types—for example, lung, heart, and liver—can ...
openaire   +1 more source

Organ-on-a-Chip: A Preclinical Microfluidic Platform for the Progress of Nanomedicine.

Small, 2020
Despite the progress achieved in nanomedicine during the last decade, the translation of new nanotechnology-based therapeutic systems into clinical applications has been slow, especially due to the lack of robust preclinical tissue culture platforms able
Raquel O. Rodrigues, P. C. Sousa, J. Gaspar, M. Bañobre‐López, R. Lima, G. Minas   +5 more
semanticscholar   +1 more source

Inflammation and epithelial–mesenchymal transition in a CFTR‐depleted human bronchial epithelial cell line revealed by proteomics and human organ‐on‐a‐chip

The FEBS Journal
Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, leading to chronic, unresolved inflammation of the airways due to uncontrolled recruitment of polymorphonuclear leukocytes (PMNs ...
D. Mattoscio, Luis A Baeza, Haiqing Bai, T. Colangelo, Simone Castagnozzi, Marta Marzotto, M. Cufaro, Virginia Lotti, Yu-Chieh Yuan, Matteo Mucci, Longlong Si, M. Zuccarini, M. Tredicine, Simona D'Orazio, D. Pieragostino, P. Del Boccio, Claudio Sorio, M. Trerotola, Mario Romano, R. Plebani   +19 more
semanticscholar   +1 more source

Organ-on-a-chip systems for vascular biology

Journal of Molecular and Cellular Cardiology, 2021
Organ-on-a-chip (OOC) platforms involve the miniaturization of cell culture systems and enable a variety of novel experimental approaches. These range from modeling the independent effects of biophysical forces on cells to screening novel drugs in multi-organ microphysiological systems, all within microscale devices.
Christian J, Mandrycky, Caitlin C, Howard, Samuel G, Rayner, Yu Jung, Shin, Ying, Zheng   +4 more
openaire   +2 more sources

Organs-on-a-chip models for biological research

Cell, 2021
We explore the utility of bioengineered human tissues-individually or connected into physiological units-for biological research. While much smaller and simpler than their native counterparts, these tissues are complex enough to approximate distinct tissue phenotypes: molecular, structural, and functional. Unlike organoids, which form spontaneously and
Gordana, Vunjak-Novakovic, Kacey, Ronaldson-Bouchard, Milica, Radisic   +2 more
openaire   +2 more sources

Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system.

Lab on a Chip, 2023
Background: COVID-19 pandemic has caused more than 6 million deaths worldwide. Co-morbid conditions such as Type 2 Diabetes (T2D) have increased mortality in COVID-19.
V. Negi, Dillon Gavlock, Mark T. Miedel, Jeong Kyung Lee, T. Shun, A. Gough, L. Vernetti, Andrew M. Stern, D. L. Taylor, Vijay K Yechoor   +9 more
semanticscholar   +1 more source

Comprehensive Development in Organ-On-A-Chip Technology

Journal of Pharmaceutical Sciences, 2022
The expeditious advancement in the organ on chip technology provided a phase change to the conventional in vitro tests used to evaluate absorption, distribution, metabolism, excretion (ADME) studies and toxicity assessments. The demand for an accurate predictive model for assessing toxicity and reducing the potential risk factors became the prime area ...
X, Joseph, V, Akhil, A, Arathi, P V, Mohanan   +3 more
openaire   +2 more sources

Organs-on-a-chip for drug discovery

Current Opinion in Pharmacology, 2013
The current drug discovery process is arduous and costly, and a majority of the drug candidates entering clinical trials fail to make it to the marketplace. The standard static well culture approaches, although useful, do not fully capture the intricate in vivo environment.
Seila, Selimović, Mehmet R, Dokmeci, Ali, Khademhosseini   +2 more
openaire   +2 more sources

Controlled microvasculature for organ-on-a-chip applications produced by high-definition laser patterning

Biofabrication
Organs-on-Chips (OoCs) are 3D models aiming to faithfully replicate in vitro specific functions of human organs or tissues. While promising as an alternative to traditional 2D cell culture and animal models in drug development, controlled realization of ...
Alice Salvadori, Masafumi Watanabe, Marica Markovic, Ryo Sudo, A. Ovsianikov   +4 more
semanticscholar   +1 more source

Neutrophilic infiltration in organ-on-a-chip model of tissue inflammation.

Lab on a Chip, 2020
The multiphasic etiology of tissue inflammation and the fundamental immunological differences between species render inflammatory pathologies difficult to recapitulate in animal models, and account for the paucity of therapies that are successfully ...
N. Gjorevski, Blandine Avignon, Régine Gérard, Lauriane Cabon, A. Roth, Michael Bscheider, A. Moisan   +6 more
semanticscholar   +1 more source