Results 131 to 140 of about 1,435,862 (389)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

The Impact of Presumed Consent Legislation on Cadaveric Organ Donation: A Cross Country Study [PDF]

In the U.S., Great Britain, and in many other countries, the gap between the demand and the supply of human organs for transplantation is on the rise, despite the efforts of governments and health agencies to promote donor registration. In some countries
Alberto Abadie, Sebastien Gay
core  

Exploring barriers to organ donation in the African American communities of California [PDF]

, 2012
There are a disproportionate number of African-Americans on transplant waiting lists across the country. The outcomes of a transplant are greatly improved when the donor and the recipient are from the same ethnic group.
Law, D. R., McNiesh, Susan
core   +1 more source

Organ donation and transplantation - public policy and clinical perspectives [PDF]

, 2012
The book provides specialist information via chapters on public policy as well as clinical developments in organ ...
Randhawa, Gurch
core   +2 more sources

Does Changing Defaults save Lives? Effects of Presumed Consent Organ Donation Policies

Behavioral Science & Policy, 2019
In this review, we examine whether presumed consent organ donation policies save lives. We compare presumed consent defaults (where people are considered organ donors by default but can opt out of donation) with explicit consent defaults (where people ...
Mary Steffel, Elanor F. Williams, David Tannenbaum   +2 more
semanticscholar   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Organs and organisations: Situating ethics in organ donation after circulatory death in the UK [PDF]

, 2018
Controlled organ donation after circulatory death (DCD) has recently been revived in the UK, as part of attempts to increase organ donation rates.
Academy of Medical Royal Colleges & UK Donation Ethics Committee, Arnold, Bell, Bell, Bernat, British Transplant Society, Brodwin, Brosnan, Button, Callaghan, Cohen, Columb, Cooper, Cooper, Corrigan, Das, De Vita, Department of Health, Department of Health, Dominguez-Gil, Fox, Fox, Gardiner, Gardiner, Gardiner, Giacomini, Hedgecoe, Heimer, Hoeyer, Hoeyer, Hoeyer, Hoeyer, Hoffmaster, Hogle, Hogle, Hosgood, Jasanoff, Jensen, Jensen, Jessie Cooper, Kierans, Kierans, Kierans, Kleinman, Lock, Lock, Lynch, Lynch, Lynch, NHS Blood and Transplant, Ortega-Deballon, Pickersgill, Rapp, Reissman, Scheper-Hughes, Sharp, Smith-Doerr, Sperling, Timmermans, Yea   +59 more
core   +1 more source

Organ donation awareness and attitude among Riyadh City Residents, Saudi Arabia

Journal of Nature and Science of Medicine, 2018
Introduction: Organ donation is widely contentious among the Saudi population though remains largely understudied. In the aim to understand the public perception of organ donation, willingness to donate, and the reasons for donation refusal, we carried ...
Aws Almufleh, Rasha Althebaity, Ali S Alamri, Nada A Al-Rashed, Eman H Alshehri, Lina Albalawi, Reem Alameer, Eman Hajr, Ismail A Raslan, Faisal A Alsaif   +9 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The Impact of Religion and Provision of Information on Increasing Knowledge and Changing Attitudes to Organ Donation: An Intervention Study

Journal of religion and health, 2019
One of the most significant developments in recent history has probably been organ donation and organ transplantation. They are frequently the only treatment available in certain cases.
F. Krupić
semanticscholar   +1 more source