Results 141 to 150 of about 1,435,862 (389)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Structural analysis of the factors pertaining to attitudes toward and consciousness of organ donation : Comparison between Japanese and Americans [PDF]

, 2007
The purpose of this study is to analyze the background factors relating to opinions on organ donation through factorial and structural comparisons between Japanese and Americans.
Cleveland SE, Conesa C, Rios A, Tamirez P and Par, Donatelli LA, Geocadin RG and Willi, DuBois JM, Schmidt T, Gosen T Ikeguchi, Gross T, Martinoli S, Spagnoli G, B, Hetzer R, IKEGUCHI EIKAN, IKEGUCHI EIKAN, IKEGUCHI EKAN, IKEGUCHI GOSEN, IKEGUCHI GOSEN, Jindal RM, Joseph JT and Baines LS, Kim JR, Fisher M and Elliott D, Kleindienst A, Haupt WF and Hildebr, Lam WA and McCullough LB, Lovasik D, Matten MR, Sliepcevich EM, Sarvele, Ohwaki K, Yano E, Shirouzu M, Kobay, Rappaport ZH, Rappaport IT, Rassin M, Lowenthal M and Silner D, Rozaidi SW, Sukro J, Dan A, Templer DI, Truog RD, Robinson WM, Truog RD, Robinson WM, Velero R, Manyalich M, Wig N, Gupta P, Kailash S, 古城幸子, 川崎泰子, 升谷由美子, 星野一正, 池口豪泉   +29 more
core   +1 more source

Empathy, social media, and directed altruistic living organ donation [PDF]

, 2018
Greg Moorlock, Heather Draper
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Association between nonalcoholic fatty liver disease and increased glucose-to-albumin ratio in adults without diabetes

Frontiers in Endocrinology
BackgroundNonalcoholic fatty liver disease (NAFLD) affects approximately 30% of individuals globally. Both serum glucose and albumin were demonstrated to be potential markers for the development of NAFLD.
Shuai Wang, Shuai Wang, Shuai Wang, Xiaohong Lin, Chuchen Zhu, Chuchen Zhu, Chuchen Zhu, Yuqi Dong, Yuqi Dong, Yuqi Dong, Yiwen Guo, Yiwen Guo, Yiwen Guo, Zhonghao Xie, Zhonghao Xie, Zhonghao Xie, Xiaoshun He, Xiaoshun He, Xiaoshun He, Weiqiang Ju, Weiqiang Ju, Weiqiang Ju, Maogen Chen, Maogen Chen, Maogen Chen   +24 more
doaj   +1 more source

IMPORTANCE OF ORGANIZATIONAL FACTORS IN OVERCOMING THE SHORTAGE OF DONOR ORGANS

Вестник трансплантологии и искусственных органов, 2011
This review highlights the main problem in organ donation practice. There was done the analysis of main orga- nizational solutions and best organ donation policy practices with accent on Spain Model of organ donation, and the comparing U.S.
I. V. Loginov, N. V. Kechaeva, O. N. Reznik   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Transferring an ICU Patient at the End of His Life for the Purpose of Organ Donation: Could It Be Considered? [PDF]

, 2022
Matthieu Le Dorze, Bénédicte Gaillard Le Roux, Gérard Audibert, Régis Quéré, Laurent Muller, Sylvain Lavoué, Jean‐Christophe Venhard, Pierre-François Pérrigault, Olivier Lesieur   +8 more
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Attitude on Nursing Ethical Values and on Brain Death Organ Donation of Hospital Nurses [PDF]

, 2011
Ye-Jean Kim, Myung‐Nam Lee
openalex   +1 more source