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Hemadsorption as a Treatment Option for Multisystem Inflammatory Syndrome in Children Associated With COVID-19. A Case Report

Frontiers in Immunology, 2021
Multisystem Inflammatory Syndrome in Children (MIS-C) associated with COVID-19 is characterized by hypercytokinemia leading to overwhelming inflammation. We describe the use of a hemadsorption device as part of the supportive treatment for cytokine storm.
Juan Carlos Ruiz-Rodríguez +20 more
doaj +1 more source

Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit

Frontiers in Medicine, 2023
ObjectivesTo determine vitamin C plasma kinetics, through the measurement of vitamin C plasma concentrations, in critically ill Coronavirus infectious disease 2019 (COVID-19) patients, identifying eventually the onset of vitamin C deficiency ...
Luis Chiscano-Camón +27 more
doaj +1 more source

The Use of CytoSorb Therapy in Critically Ill COVID-19 Patients: Review of the Rationale and Current Clinical Experiences

Critical Care Research and Practice, 2021
The COVID-19 pandemic has led to the biggest global health crisis of our lifetime. There is accumulating evidence that a substantial number of critically ill COVID-19 patients exhibit a dysregulated host response manifesting as cytokine storm or cytokine
Juan Carlos Ruiz-Rodríguez +3 more
doaj +1 more source

Cytokine Hemoadsorption as Rescue Therapy for Critically Ill Patients With SARS-CoV-2 Pneumonia With Severe Respiratory Failure and Hypercytokinemia

Frontiers in Medicine, 2022
Introduction: A dysregulated inflammatory response, known as “cytokine storm”, plays an important role in the pathophysiology of coronavirus 2019 disease (COVID-19).
Juan Carlos Ruiz-Rodríguez +18 more
doaj +1 more source

Case report: Cytokine hemoadsorption in a case of hemophagocytic lymphohistiocytosis secondary to extranodal NK/T-cell lymphoma

Frontiers in Medicine, 2022
We discuss a single case of Hemophagocytic lymphohistiocytosis (HLH) due to NK-type non-Hodgkin lymphoma and Epstein-Barr virus reactivation with multiorgan dysfunction and distributive shock in which we performed cytokine hemoadsorption with Cytosorb ®.
Juan Carlos Ruiz-Rodríguez +38 more
doaj +1 more source

JAK2-STAT Epigenetically Regulates Tolerized Genes in Monocytes in the First Encounter With Gram-Negative Bacterial Endotoxins in Sepsis

Frontiers in Immunology, 2021
Microbial challenges, such as widespread bacterial infection in sepsis, induce endotoxin tolerance, a state of hyporesponsiveness to subsequent infections. The participation of DNA methylation in this process is poorly known.
Octavio Morante-Palacios +11 more
doaj +1 more source

Epigenetic and transcriptomic reprogramming in monocytes of severe COVID-19 patients reflects alterations in myeloid differentiation and the influence of inflammatory cytokines

Genome Medicine, 2022
Background COVID-19 manifests with a wide spectrum of clinical phenotypes, ranging from asymptomatic and mild to severe and critical. Severe and critical COVID-19 patients are characterized by marked changes in the myeloid compartment, especially ...
Gerard Godoy-Tena +13 more
doaj +1 more source

Phase I pharmacokinetic study of single agent trametinib in patients with advanced cancer and hepatic dysfunction

Journal of Experimental & Clinical Cancer Research, 2022
Background Trametinib is an oral MEK 1/2 inhibitor, with a single agent recommended phase 2 dose (RP2D) of 2 mg daily (QD). This study was designed to evaluate RP2D, maximum tolerated dose (MTD), and pharmacokinetic (PK) profile of trametinib in patients
Pei Jye Voon +18 more
doaj +1 more source

Shock volume: Patient-specific cumulative hypoperfusion predicts organ dysfunction in a prospective cohort of multiply injured patients [PDF]

, 2018
BACKGROUND: Multiply injured patients are at risk of developing hemorrhagic shock and organ dysfunction. We determined how cumulative hypoperfusion predicted organ dysfunction by integrating serial Shock Index measurements. METHODS: In this study,
Bell, Teresa M. +6 more
core +2 more sources

Levosimendan in Sepsis. [PDF]

, 2017
Commentum to "Levosimendan for the Prevention of Acute Organ Dysfunction in ...
Morelli, Andrea, Tritapepe, Luigi
core +1 more source

intensive care medicine
multiple organ dysfunction syndrome
immunology

disease
biology
septic shock

intensive care
emergency medicine
intensive care unit