Frontiers in NeurologyBackgroundDexmedetomidine (DEX) has demonstrated potential as an effective agent for enhancing early postoperative cognitive function. However, there is ongoing debate regarding its optimal dosage and impact on early postoperative inflammatory response ...
Cuifang Huang +16 more
doaj +1 more source
The impact of acute organ dysfunction on patients′ mortality with severe sepsis
Journal of Anaesthesiology Clinical Pharmacology, 2011 Background: Severe sepsis leads to organ failure and results in high mortality. Organ dysfunction is an independent prognostic factor for intensive care unit (ICU) mortality.
Takeshi Umegaki +2 more
doaj +1 more source
Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis [PDF]
, 2013 Funding This study was funded by the Medical Research Council (Grant number G0800149). Research material from this study is not available. Acknowledgement We are very grateful to Dr Robin A.J. Smith, Department of Chemistry, University of Otago, Dunedin,
Galley, H. F. +3 more
core +1 more source
Scientific ReportsMannitol is widely used for treating brain edema caused by various diseases, but it has been reported to cause acute kidney injury. However, the prognosis for patients with non-traumatic intracerebral hemorrhage who also have acute kidney injury and ...
Weixiao Chen +8 more
doaj +1 more source
Drug treatment of hypertension: focus on vascular health [PDF]
, 2016 Hypertension, the most common preventable risk factor for cardiovascular disease and death, is a growing health burden. Serious cardiovascular complications result from target organ damage including cerebrovascular disease, heart failure, ischaemic heart
Cameron, Alan C. +2 more
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Current perspectives in the management of sepsis and septic shock
Frontiers in MedicineWithin patients with sepsis, there exists significant heterogeneity, and while all patients should receive conventional therapy, there are subgroups of patients who may benefit from specific therapies, often referred to as rescue therapies.
Luis Chiscano-Camón +22 more
doaj +1 more source
Feasibility of the modified sequential organ function assessment score in a resource-constrained setting: a prospective observational study. [PDF]
, 2017 BackgroundSub-Saharan Africa has a great burden of critical illness with limited health care resources. We evaluated the feasibility and utility of the modified Sequential Organ Function Assessment (mSOFA) score in assessing morbidity and mortality in ...
Ejoku, Joseph +8 more
core +2 more sources
Mechanism of Mitophagy and Its Role in Sepsis Induced Organ Dysfunction: A Review
Frontiers in Cell and Developmental Biology, 2021 Autophagy, an evolutionarily conserved process, plays an important role in maintaining cellular homeostasis under physiological and pathophysiological conditions.
Cheng-long Zhu +7 more
doaj +1 more source
BMC Infectious Diseases, 2023 Background The organ dysfunction that is associated with death in COVID-19 patients has not been determined in multicenter epidemiologic studies. In this study, we evaluated the major association with death, concomitant organ dysfunction, and proportion ...
Ryuichi Nakayama +10 more
doaj +1 more source
Statin therapy in critical illness : an international survey of intensive care physicians' opinions, attitudes and practice [PDF]
, 2012 Background Pleotropic effects of statins on inflammation are hypothesised to attenuate the severity of and possibly prevent the occurrence of the host inflammatory response to pathogen and infection-related acute organ failure.
Di Gangi, Stefania +6 more
core +1 more source